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When planning routes, drivers usually consider a multitude of different travel costs, e.g., distances, travel times, and fuel consumption. Different drivers may choose different routes between the same source and destination because they may have different driving preferences (e.g., time-efficient driving v.s. fuel-efficient driving). However, existing routing services support little in modeling multiple travel costs and personalization-they usually deliver the same routes that minimize a single travel cost (e.g., the shortest routes or the fastest routes) to all drivers.We study the problem of how to recommend personalized routes to individual drivers using big trajectory data. First, we provide techniques capable of modeling and updating different drivers' driving preferences from the drivers' trajectories while considering multiple travel costs. To recommend personalized routes, we provide techniques that enable efficient selection of a subset of trajectories from all trajectories according to a driver's preference and the source, destination, and departure time specified by the driver. Next, we provide techniques that enable the construction of a small graph with appropriate edge weights reflecting how the driver would like to use the edges based on the selected trajectories. Finally, we recommend the shortest route in the small graph as the personalized route to the driver. Empirical studies with a large, real trajectory data set from 52,211 taxis in Beijing offer insight into the design properties of the proposed techniques and suggest that they are efficient and effective.

Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Its anti-HIV-1 activity was tested in the present study. Results showed that xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC50 values were 0.82, 1.28 and 0.50 microg/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC50 value of 20.74 microg/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by xanthohumol. The results from this study suggested that xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection. However, the mechanism of its anti-HIV-1 effect needs to be further clarified.

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We are witnessing increasing interests in developing "smart cities" which helps improve the efficiency, reliability, and security of a traditional city. An important aspect of developing smart cities is to enable "smart transportation," which improves the efficiency, safety, and environmental sustainability of city transportation means. Meanwhile, the increasing use of GPS devices has led to the emergence of big trajectory data that consists of large amounts of historical trajectories and real-time GPS data streams that reflect how the transportation networks are used or being used by moving objects, e.g., vehicles, cyclists, and pedestrians. Such big trajectory data provides a solid data foundation for developing various smart transportation applications, such as congestion avoidance, reducing greenhouse gas emissions, and effective traffic accident response, etc. Instead of proposing yet another specific smart transportation application, we propose the Parallel-Distributed Network-constrained Moving Objects Database (PD-NMOD), a general framework that manages big trajectory data in a scalable manner, which provides an infrastructure that is able to support a wide variety of smart transportation applications and thus benefiting the smart city vision as a whole. The PD-NMOD manages both transportation networks and trajectories in a distributed manner. In addition, the PD-NMOD is designed to support general SQL queries over moving objects and to efficiently process the SQL queries on big trajectory data in parallel. Such design facilitates smart transportation applications to retrieve relevant trajectory data and to conduct statistical analyses. Empirical studies on a large trajectory data set collected from 3,500 taxis in Beijing offer insight into the design properties of the PD-NMOD and offer evidence that the PD-NMOD is efficient and scalable.

Recent advances on the Internet of Things (IoT) have posed great challenges to the search engine community. IoT systems manage huge numbers of heterogeneous sensors and/or monitoring devices, which continuously monitor the states of real-world objects, and most data are generated automatically through sampling. The sampling data are dynamically changing so that the IoT search engine should support real-time retrieval. Additionally, the IoT search involves not only keyword matches but also spatial-temporal searches and value-based approximate searches, as IoT sampling data are generally from spatial-temporal scenario. To meet these challenges, we propose a 'Hybrid Real-time Search Engine Framework for the Internet of Things based on Spatial-Temporal, Value-based, and Keyword-based Conditions' ('IoT-SVK Search Engine' or simply 'IoT-SVKSearch' for short) in this paper. The experiments show that the IoT-SVK search engine has satisfactory performances in supporting real-time, multi-modal retrieval of massive sensor sampling data in the IoT.Note that the longitude and latitude values are contained in the pos attributed instead of in the value attribute, so that they are not component values.(1) First, compute the search range Q Range by taking (t q , cValue q ) as the center and the error threshold as the extent, as shown in Figure 9. That is,

Tracking and managing the locations of moving objects are essential in modern intelligent transportation systems (ITSs). However, a number of limitations in existing methods make them unsuitable for real-world ITS applications. In particular, Euclidean-based methods are not accurate enough in representing locations and in analyzing traffic, unless the locations are frequently updated. Network-based methods require either digital maps to be installed in moving objects or transmission of prediction policies, which inevitably increase the cost. To solve these problems, we propose a network-matched trajectory-based moving-object database (NMTMOD) mechanism and a traffic flow analysis method using the NMTMOD. In the NMTMOD, the locations of moving objects are tracked through a dense sampling and batch uploading strategy, and a novel edge-centric networkmatching method, which is running at the server side, is adopted to efficiently match the densely sampled GPS points to the network. In addition, a deviation-based trajectory optimization method is provided to minimize the trajectory size. Empirical studies with large real trajectory data set offer insight into the design properties of the proposed NMTMOD and suggest that the NMTMOD significantly outperforms other mobile-map free-moving-object database models in terms of precision of both location tracking and network-based traffic flow analysis.Index Terms-Moving-object database, network-matched trajectory, spatiotemporal database, traffic flow analysis.

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