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Grouting reinforcement technology gradually has been widely used to repair the subgrade settlement diseases, but the current single application of discrete element software or finite element software cannot effectively simulate the grouting process. Therefore, one new method is put forward in the research of grouting based on the CFD-DEM coupling principle. And then, one typical subgrade section in the Shanghai–Nanjing intercity railway is used to simulate the grouting process and diffusion mechanism of slurry from microlevel. Based on the results of site survey, some findings are shown as follows: First, the new method is feasible which integrates the favorable aspects of discrete elements, finite elements, and boundary elements. Second, the greater the grouting pressure, the greater the influence range of grouting, and it shows six petals shape. When the grouting pressure is small, the grouting generally shows penetration or extrusion grouting, and its influence range is small. When the grouting pressure is large enough, it is characterized by splitting grouting, and the influence range of grouting is getting larger and larger. Third, the growth rates of influence range gradually increase with the increasement of grouting pressures, and the reasonable selection of grouting pressures is very important.

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