Support vector machine (SVM), partial least squares (PLS), and Back-Propagation artificial neural network (ANN) were employed to establish QSAR models of 2 dipeptide datasets. In order to validate predictive capabilities on external dataset of the resulting models, both internal and external validations were performed. The division of dataset into both training and test sets was carried out by D-optimal design. The results showed that support vector machine (SVM) behaved well in both calibration and prediction. For the dataset of 48 bitter tasting dipeptides (BTD), the results obtained by support vector regression (SVR) were superior to that by PLS in both calibration and prediction. When compared with BP artificial neural network, SVR showed less calibration power but more predictive capability. For the dataset of angiotensin-converting enzyme (ACE) inhibitors, the results obtained by support vector machine (SVM) regression were equivalent to those by PLS and BP artificial neural network. In both datasets, SVR using linear kernel function behaved well as that using radial basis kernel function. The results showed that there is wide prospect for the application of support vector machine (SVM) into QSAR modeling.Keywords: support vector machine (SVM), partial least squares (PLS), back-propagation (BP) artificial neural network (ANN), quantitative structure-activity relationship (QSAR).
Cloud cover is an important factor limiting the earth observation efficiency of optical imaging satellites. Existing solutions include avoiding cloudy observation time windows by onboard cloud detectors and ground monitors, which are difficult to improve satellite observation efficiency in time. In order to solve the problem, firstly, a Geostationary Earth Orbit (GEO) and Low Earth Orbit (LEO) satellites cooperation scheme by using cloud cover information provided by GEO meteorological satellite to guide the imaging of LEO optical satellites is proposed, and the operation flow and key elements in this scheme are analyzed. Secondly, Fengyun-4 GEO meteorological satellite and its cloud mask (CLM) products are analyzed. Thirdly, an autonomous mission planning algorithm based on real-time cloud cover information is proposed. Computational results have demonstrated the effectiveness of the proposed GEO–LEO satellites cooperation scheme by taking the actual orbit and payload data of Fengyun-4 and Gaofen-1/2 satellites as examples.
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