Abstract:As an important node in the power grid, substation plays a very important role in the whole power grid. The equipment operation of the substation is carried out in order to timely and effectively detect the operation status of the equipment, find the latent fault of the equipment, and the maintenance of the substation is necessary for safe operation.However, there are some safety problems in the operation of the substation, which need to analyze the status quo of its safe operation and formulate the corresponding improvement measures. Based on this, this article on the substation maintenance work safety measures for a brief analysis, hoping to provide for future reference.Key words: substation; maintenance; safety measures The importance of substation maintenance safety researchIn the substation operation process, which will be subject to many factors, including environmental factors and human factors, thus affecting the safety operation of substations, and even a variety of failures. Therefore, we must strengthen the daily maintenance of substation equipment, a variety of equipment for regular maintenance. In the substation equipment maintenance site there will be more influencing factors that we need to analyze, find out the dangerous points and then develop appropriate technical measures to improve. In the process of analysis and research, we should fully consider the various environmental changes and risk factors faced by maintenance personnel, and cannot affect the maintenance work. Therefore, it is very important to do a good job in the safety work of substation maintenance. Substation equipment maintenance content Bus repairmentThe 10 kV side switchgear is connected to the low side of the main transformer of the station via a tubular insulated conductor, and the tubular insulated conductor is used as a 10 kV bus. This type of bus for the hollow conductor, insulation for the sealed shield, the main insulation material with excellent performance and stability of PTFE. But when it is used as a long distance contact, the joint installation process is more difficult. In the case of a large stone station, for example, the installer performs heat shrinkage at the pipe joint connection, and the process does not regulate
Background: B lymphocyte-induced maturation protein 1 (Blimp1) is a risk allele for rheumatoid arthritis (RA), but its functional mechanism in RA remains to be further explored.Methods: Flow cytometry was performed to detect CD4 + T cell differentiation. ELISA was used to measure inflammatory factor secretion. Lentivirus mediated Blimp1 overexpression vector (LV-Blimp1) or short hairpin RNA (sh-Blimp1) were used to infect CD4 + T cells stimulated by anti-CD28 and anti-CD3 mAbs. RA fibroblast-like synoviocytes (FLSs) were co-cultured with CD4 + T cells or T cell conditioned medium (CD4CM), and cell proliferation, invasion, and expression of adhesion molecules and cytokines in FLSs were evaluated. Mice were injected intradermally with type II collagen to establish a collagen-induced arthritis (CIA) mouse model, and the severity of CIA was evaluated with H&E and Safranin-O staining. Results: Blimp1 knockdown increased pro-inflammatory factor secretion, but downregulated IL-10 concentration in activated CD4 + T cells. Blimp1 overexpression promoted regulatory T cells (Treg) CD4 + T cell differentiation and hindered T helper 1 (Th1) and T helper 17 (Th17) CD4 + T cell differentiation. Blimp1 overexpression suppressed the expression of pro-inflammatory factors and adhesion molecules in CD4 + T cells by upregulating IL-10. Moreover, Blimp1 overexpression impeded the enhanced effect of CD4 + T cells/CD4CM on cell adhesion, inflammation, proliferation, invasion and RhoA and Rac1 activities in FLSs by upregulating IL-10. Additionally, administration with LV-Blimp1 alleviated the severity of CIA. Conclusion: Blimp1 restrained CD4 + T cells-induced activation of FLSs by promoting the secretion of IL-10 in CD4 + T cells via the Rho signaling pathway.
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