No abstract

Antibody-decorated liposomes can facilitate the precise delivery of chemotherapeutic drugs to the lung by targeting a recognition factor present on the surface of lung tumor cells. Carbonic anhydrase IX (CA IX) is an enzyme expressed on the surface of lung cancer cells with a restricted expression in normal lungs. Here, we explored the utility of anti-carbonic anhydrase IX (CA IX) antibody, conjugated to the surface of triptolide (TPL)-loaded liposomes (CA IX-TPL-Lips), to promote the therapeutic effects for lung cancer via pulmonary administration. It was found that the CA IX-TPL-Lips significantly improved the cellular uptake efficiency in both CA IX-positive human non-small cell lung cancer cells (A549) and A549 tumor spheroids, resulting in the efficient cell killing compared with free TPL and non-targeted TPL-Lips. In vivo, CA IX-Lips via pulmonary delivery showed specificity and a sustained release property resided up to 96 h in the lung, both of which improved the efficiency of TPL formulations in restraining tumor growth and significantly prolonged the lifespan of mice with orthotopic lung tumors. The results suggest that CA IX-decorated liposomes can potentially be used as an effective therapeutic strategy for lung cancer.

Abstract. Located in western Inner Mongolia, the Badain Jaran Desert is the second largest desert in China and consists of a regular series of stable megadunes, among which over 70 permanent lakes exist. The unexpected lakes in desert attracted research interests on exploring the hydrological process under this particular landscape; however, a very few literatures exist on the diurnal and spatial variation of the drying front in this area, which is the main issue in the desert hydrological process to characterize the movement of water in soil. In order to understand the drying front in the Badain Jaran Desert, a field campaign was conducted by the observations of soil physical parameters and micrometeorological parameters. With the field data, the performance of a vadose zone soil water balance model, the HYDRUS, was verified and calibrated. Then, the HYDRUS was used to produce the spatial and temporal information of coupled water, water vapour and heat transport in sand to characterize the variation pattern of the drying front before, during and after the rainfall. Finally, the deepest drying front was applied to determine the effective infiltration, which is defined as the amount of soil water captured by the sand beneath the deepest drying front by infiltrating water of an incident rainfall event.

No abstract

The gut microbiota and their metabolites could play an important role in health and diseases of human beings. Short-chain fatty acids (SCFAs) are mainly produced by gut microbiome fermentation of dietary fiber and could also be produced by bacteria of the skin and vagina. Acetate, propionate, and butyrate are three major SCFAs, and their bioactivities have been widely studied. The SCFAs have many health benefits, such as anti-inflammatory, immunoregulatory, anti-obesity, anti-diabetes, anticancer, cardiovascular protective, hepatoprotective, and neuroprotective activities. This paper summarizes health benefits and side effects of SCFAs with a special attention paid to the mechanisms of action. This paper provides better support for people eating dietary fiber as well as ways for dietary fiber to be developed into functional food to prevent diseases.