Objectives This study was conducted to identify the significantly altered long noncoding RNAs (lncRNAs), messenger RNA (mRNA) and pathways in gastric cancer (GC). Methods We used microarray analysis to identify differentially expressed lncRNAs and mRNAs, whereas the obviously changed pathways were found by gene set enrichment analysis. The coexpression network of lncRNA and mRNA was constructed by Cytoscape, and their target relationships with miRNAs were predicted by miRcode and TargetScan. qRT‐PCR and Western blot were performed to determine the expression levels of mRNAs and proteins in tissues and cell lines. Dual‐luciferase reporter assay was applied to achieve the determination of the specific target relationships. Cell viability, migration, and apoptosis were detected by MTT assay, wound healing assay and flow cytometry, respectively. Through the xenograft assay, the gastric tumor was implanted into nude mice to investigate the influence of HOTAIRM1 in vivo. Results HOTAIRM1 and phosphatase and tensin homolog (PTEN) were both downregulated in GC, whereas miR‐17‐5p was upregulated. Moreover, the PI3K/AKT pathway was found activated in GC. HOTAIRM1 targeted miR‐17‐5p, whereas PTEN was the downstream target gene of miR‐17‐5p. HOTAIRM1 suppressed proliferation and migration of GC cell line and induced their apoptosis, whereas miR‐17‐5p played the opposite role on GC cell line. HOTAIRM1 also postponed tumor growth in vivo and inhibited the PI3K/AKT pathway in GC. Conclusions LncRNA HORAIRM1 suppressed the PI3K/AKT pathway in GC and inhibited the progression of GC by serving as a competing endogenous RNA of miR‐17‐5p, mediating the expression of PTEN.

The purpose of the study is to investigate the relation between government expenditure and private investment in China during 1978China during to 2004. To this end, effects of three categories of government on private investment are examined within the cointegration and error-correction framework. The empirical results show that government investment expenditure crowds out private investment in the short-term whereas crowds in private investment in the long-run. The government consumption expenditure and government transfer expenditure crowd out private investment, but the effect is not significance.