A direct and site-specific alkylation
of (sp3)C–H
bond with aliphatic boronic acid was achieved. By simply heating glycinates
and amines together with alkylboronic acids under an oxygen atmosphere,
a variety of unnatural α-amino acids and peptides could be obtained
in good yields.
We reported herein an electrochemically reductive alkylation, allylation and propargylation of quinoxalin-2(1H)-ones with haloalkanes. In an undivided cell, treatment of quinoxalin-2(1H)-ones and alkyl halides with constant current, a wide range of 3-alkylated-3,4-dihydroquinoxalin-2(1H)-one and its derivatives can be isolated in 25-87% yields.
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