Objectives. To investigate a deep learning reconstruction algorithm to reduce the time of synthetic MRI (SynMRI) scanning on the breast and improve the image quality. Materials and Methods. A total of 192 healthy female volunteers (mean age: 48.1 years) underwent the breast MR examination at 3.0 T from September 2020 to June 2021. Standard SynMRI and fast SynMRI scans were collected simultaneously on the same volunteer. Deep learning technology with a generative adversarial network (GAN) was used to generate high-quality fast SynMRI images by end-to-end training. Peak signal-to-noise ratio (PSNR), mean squared error (MSE), and structural similarity index measure (SSIM) were used to compare the image quality of generated images from fast SynMRI by deep learning algorithms. Results. Fast SynMRI acquisition time is half of the standard SynMRI scan, and the generated images of the GAN model show that PSNR and SSIM are improved and MSE is reduced. Conclusion. The application of deep learning algorithms with GAN model in breast MAGiC MRI improves the image quality and reduces the scanning time.
Background Lymphovascular space invasion (LVSI) of endometrial cancer (EC) is a postoperative histological index, which is associated with lymph node metastases. A preoperative acknowledgement of LVSI status might aid in treatment decision-making. Purpose To explore the utility of multiparameter magnetic resonance imaging (MRI) and radiomic features obtained from intratumoral and peritumoral regions for predicting LVSI in endometrioid adenocarcinoma (EEA). Material and Methods A total of 334 EEA tumors were retrospectively analyzed. Axial T2-weighted (T2W) imaging and apparent diffusion coefficient (ADC) mapping were conducted. Intratumoral and peritumoral regions were manually annotated as the volumes of interest (VOIs). A support vector machine was applied to train the prediction models. Multivariate logistic regression analysis was used to develop a nomogram based on clinical and tumor morphological parameters and the radiomics score (RadScore). The predictive performance of the nomogram was assessed by the area under the receiver operator characteristic curve (AUC) in the training and validation cohorts. Results Among the features obtained from different imaging modalities (T2W imaging and ADC mapping) and VOIs, the RadScore had the best performance in predicting LVSI classification (AUCtrain = 0.919, and AUCvalidation = 0.902). The nomogram based on age, CA125, maximum anteroposterior tumor diameter on sagittal T2W images, tumor area ratio, and RadScore was established to predict LVSI had AUC values in the training and validation cohorts of 0.962 (sensitivity 94.0%, specificity 86.0%) and 0.965 (sensitivity 90.0%, specificity 85.3%), respectively. Conclusion The intratumoral and peritumoral imaging features were complementary, and the MRI-based radiomics nomogram might serve as a non-invasive biomarker to preoperatively predict LVSI in patients with EEA.
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