Metalaxyl, an acylalanine fungicide, was synthesized through catalytic continuous sequentialflow reactions. Commonly used syntheses of this compound use batch systems and suffer from problems such as coproduction of halogen-containing by-products derived from acyl and alkyl halides in the substitution reactions of 2,6-dimethylaniline. To minimize waste and enhance efficiency, a halidefree approach including two continuous-flow catalytic processes, heterogeneous Pt-catalyzed reductive alkylation and homogeneous acid-catalyzed amidation with an acid anhydride, was developed. Systematic examination of the two reactions in flow mode enabled a high-yielding, two-step sequential continuous-flow process to be achieved.
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