Pseudoaspidinol is a phloroglucinol derivative with Antifungal activity and is a major active component of Dryopteris fragrans. In our previous work, we studied the total synthesis of pseudoaspidinol belonging to a phloroglucinol derivative and investigated its antifungal activity as well as its intermediates. However, the results showed these compounds have low antifungal activity. In this study, in order to increase antifungal activities of phloroglucinol derivatives, we introduced antifungal pharmacophore allylamine into the methylphloroglucinol. Meanwhile, we remained C1–C4 acyl group in C-6 position of methylphloroglucinol using pseudoaspidinol as the lead compound to obtain novel phloroglucinol derivatives, synthesized 17 compounds, and evaluated antifungal activities on Trichophyton rubrum and Trichophyton mentagrophytes in vitro. Molecular docking verified their ability to combine the protein binding site. The results indicated that most of the compounds had strong antifungal activity, in which compound 17 were found to be the most active on Trichophyton rubrum with Minimum Inhibitory Concentration (MIC) of 3.05 μg/mL and of Trichophyton mentagrophytes with MIC of 5.13 μg/mL. Docking results showed that compounds had a nice combination with the protein binding site. These researches could lay the foundation for developing antifungal agents of clinical value.
Longitudinal dynamic problems of nanorods or nanobars are analyzed based on the nonlocal elasticity theory and Bishop's assumptions. Radial deformation and inertia are considered. A governing equation for axial motion of circular nanorods is derived via Hamilton's principle. The phase speed of longitudinal waves is determined in explicit form and the dispersion curve is displayed. Exact frequency equations for clamped-free, clamped-clamped, and free-free nanorods are obtained and mode shapes are derived. A unified approximation for low frequencies is given and compared with exact results. The Love theory of nonlocal rods is a special case of the present with shear stiffness vanishing. Classical Bishop and Love rod theories can be recovered only letting the size effect disappear. The simple nonlocal rod model is reduced if setting Poisson's ratio to zero. Illustrative examples of nanofibers and nanotubes are given to show the influence of the nonlocal scale parameter on the phase speed and the natural frequencies.
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