The engine cooling system must be able to match up with the stable operating conditions so as to guarantee the engine performance. On the working cycle level, however, the dynamic thermo-state of engines has not been considered in the cooling strategy. Besides, the frequent over-cooling boiling inside the gallery changes the cooling capacity constantly. It is necessary to study the coupling effect caused by the interaction of cooling flow and in-cylinder combustion so as to provide details of the dynamic control of cooling systems. To this end, this study develops a coupled modeling scheme of the cooling process considering the interaction of combustion and coolant flow. The global reaction mechanism is used for the combustion process and the multiphase flow method is employed to simulate the coolant flow considering the wall boiling and the interphase forces. The two sub-models exchange information of in-cylinder temperature, heat transfer coefficient, and wall temperature to achieve the coupled computation. The proposed modeling process is verified through the measured diesel engine power, in-cylinder pressure, and fire surface temperature of cylinder head. Then the effects of different cooling conditions on the cyclic engine performances are analyzed and discussed.
Background
Non-small cell lung cancer is a common type of lung cancer. Piperlongumine (PL), which is extracted from the roots of piperaceae plant, long pepper, and peppercorn, is an alkaloid amide that inhibits tumor growth and metastasis. However, whether it affects lung cancer cells remains unclear.
Methods
We assessed the effects of PL on the proliferation and apoptosis of A549 and H1299 NSCLC cell lines.
Results
PL was mildly toxic to normal human bronchial epithelial cells and significantly suppressed growth and facilitated apoptosis of A549 and H1299 cells. It also upregulated microRNA (miR)-34b-3p and downregulated the transforming growth factor beta type I receptor (TGFBR1). The dual-luciferase reporter assay showed that TGFBR1 is a target gene of miR-34b-3p. Silencing of miR-34b-3p or overexpression of TGFBR1 partially attenuated the effects of PL on A549 and H1299 cells.
Conclusions
PL inhibits proliferation and induces apoptosis of A549 and H1299 cells by upregulating miR-34b-3p and modulating TGFBR1 signaling pathway.
Bubble diameter is important for the three-dimensional nucleate boiling two-phase flow simulation. However, the bubble diameter is rarely considered as a variable because it is difficult to estimate. In this paper, a novel bubble diameter model is proposed for the boiling flow. The heat transfer growth, the breakup or coalescence of collision and the liquid impacting separation are considered as the factors affecting the bubble diameter, and three bubble diameter sub-models are developed to calculate the overall bubble diameter based on a departure diameter. In the model, the heat transfer growth is calculated after estimating the bubble location. The collision variation is deduced from the interfacial area concentration equation. The liquid impacting variation is calculated through phase interaction force and gas viscous force. The proposed model is conducted through global information searching in the flow boiling simulation and validated using the void fraction and temperature data from the literature. The effects of the heat transfer growth, the collision, and the separating volume on the bubble diameter are discussed.
Abstract. As the plastic component has the advantage of the lightweight, they are used widely in the industry and many researches are conducted simultaneously; In this study, combined the elastic constitutive model and the fiber orientation, the simulations of the plastic square plate with two material definitions are carried out. They are the orthotropic material and the anisotropic material respectively. Through the simulation comparisons, the anisotropic behaviors on the thermal field, the pressure field and the vibration characteristics of the fiber reinforced PA66 are all analyzed. The results show that the different material definitions have important influence on the structure analysis. It offers the guidance for the design and analysis of the plastic component.
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