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The solubility of active pharmaceutical ingredients in various solvents is crucial to their industrial production and the development to final formulations. In this work, the solubility of rivaroxaban (form I) in the binary solvent mixtures of 1-methyl-2-pyrrolidinone with water, methanol, ethanol, and isopropanol from 273.15 to 323.15 K has been experimentally measured. Meanwhile, the dependence of the measured solubility on the temperature as well as on the composition of solvent mixtures has been simulated by Jouyban-Acree (JA) and nonrandom two liquid (NRTL) equations, respectively. The results show that as to the solubility simulation of the studied system JA and NRTL give average relative deviations of 0.1081 and 0.1064, respectively, suggesting that both JA and NRTL can act as an efficient simulation tool for the solubility of rivaroxaban (form I) in pure and mixture solvents at various temperatures.

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