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Breath analysis is a noninvasive diagnostic method that profiles a person's physical state by volatile organic compounds in the breath. It has huge potential in the field of disease diagnosis. In order to offer opportunities for practical applications, various GC-based techniques have been investigated for on-line breath analysis since GC is the most preferred technique for mixed gas separation. This article reviews the development of breath analysis and GC-based techniques in basic breath research, involving sampling methods, preconcentration methods, conventional GC-based techniques, and newly developed GC techniques for breath analysis. The combination of GC and newly developed detection techniques takes advantages of the virtues of each. In addition, portable GC or micro GC are poised to become field GC-based techniques in breath analysis. Challenges faced in GC-based techniques for breath analysis are discussed candidly. Effective cooperation of experts from different fields is urgent to promote the development of breath analysis.

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