The machining methodologies of spiral bevel gears based on universal computer numerical control (CNC) machine tools open up a new way for the flexible and diversified machining of spiral bevel gears. In order to improve the information interrelatedness and traceability in isolated machining mode of spiral bevel gears based on universal CNC machine tools, a novel integrated design and machining mode of spiral bevel gears based on universal CNC machine tools is proposed in this paper, and the spiral bevel gears integrated design and machining scheme is established. On this basis, a communication control framework for spiral bevel gear integrated design and machining is set up, and an information integration management system for spiral bevel gears is developed, which achieve the information communication and integration management of the whole spiral bevel gear integrated design and machining process. Finally, the feasibility and practicability of the integrated design and machining mode and the information integration management system are verified by the integrated design and machining example of one kind of spiral bevel gears. The proposed integrated design and machining mode accomplishes the isolated-to-integrated transformation of spiral bevel gear machining mode based on universal CNC machine tools and meets the modern integrated design and machining demands for spiral bevel gears based on universal CNC machine tools.
BACKGROUND
Dandy-Walker malformation (DWM) was first reported in 1914. In this case report, a pediatric case was complicated with giant and isolated arachnoid cysts in the right cerebellar hemisphere along with the typical DWM.
CASE SUMMARY
The patient was at 20 mo old boy, with the complaint of staggering for more than 2 mo. He was admitted to the hospital due to high intracranial pressure and staggering. At admission, the patient had typical manifestations of high intracranial pressure, including vomiting, poor appetite and feeding difficulty. Physical examination revealed increased head circumference, closed anterior fontanelle, unstable standing, staggering, leaning right while walking and ataxia. After admission, he was diagnosed with DWM accompanied by giant isolated arachnoid cysts in the posterior fossa. He underwent Y-shaped three-way valve repair for treating differential pressure between the supratentorial hydrocephalus and the subtentorial arachnoid cysts at once. The child recovered well after the surgery.
CONCLUSION
In this case, supratentorial and subtentorial shunts were placed, which solved the problem of differential pressure between the supratentorial and subtentorial parts simultaneously. This provides useful information regarding treatment exploration in this rare disease.
Accumulating studies revealed association between development of glioma and miRNA dysregulation. A case in point is miR-381-3p, but its mechanism in glioma is unclear yet. In this work, we confirmed that overexpressed miR-381-3p repressed biological functions of glioma cells. Additionally, we also discovered that upregulated anthrax toxin receptor 1 (ANTXR1) was negatively mediated by miR-381-3p. We further proved that miR-381-3p-targeted ANTXR1 was able to counteract the suppression of miR-381-3p on biological functions of glioma. We concluded that miR-381-3p and ANTXR1 were both important factors in modulating glioma progression. miR-381-3p/ANTXR1 axis is expected to be a molecular target for glioma.
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