Background
Diabetes mellitus (DM) is linked to an increased risk of lung cancer; however, the exact molecular basis is unclear.
Methods
We used a microarray method and found a group of microRNAs differently expressed in lung cancer cells at high or low glucose treatment.
Results
Among these, miR‐194 changed significantly, which indicated further analysis. miR‐194 was significantly downregulated in non‐small cell lung cancer (NSCLC) cells cultured in high glucose (HG) medium and clinical NSCLC tissues with DM. The introduction of miR‐194 significantly suppressed the proliferation, migration, and invasion of lung cancer cells induced by HG, suggesting that miR‐194 may be a suppressor during HG‐induced NSCLC progression. Further analysis indicated that
NFAT5
was a direct target gene of miR‐194, evidenced by the direct binding of miR‐194 with the 3’untranslated region of
NFAT5
. MiR‐194 could decrease the expression of
NFAT5
at both messenger RNA and protein levels, while overexpression of
NFAT5
reversed the decreased proliferation, migration, and invasion ability mediated by miR‐194 in lung cancer cells.
Conclusion
Our findings provide new insight into the mechanism of NSCLC progression. Therapeutically, miR‐194 may serve as a potential target for the treatment of lung cancer patients with DM.
The digital economy has been a great impetus to the sustainable development of enterprises. This study aims to analyze the impact and mechanism of the digital economy on the sustainable development of enterprises of the digital economy on the sustainable development of enterprises and its mechanism. Therefore, on the basis of measuring the level of urban digital economy and the level of sustainable development of enterprises, this study empirically analyzed the impact of the digital economy on enterprise sustainable development and its mechanism by using panel data of 280 A-share listed companies in cities from 2011 to 2019. The research shows that, first, the digital economy and sustainable development of enterprises have obvious spatial differentiation characteristics. Second, the digital economy can significantly promote the sustainable development of enterprises and play a role through regional innovation and entrepreneurship. In addition, compared with the midwest, the promotion effect of the east is more significant. At the provincial level, the promotion effect is better in the developed eastern provinces, such as Jiangsu, Zhejiang and Guangdong. The digital economy promotion effect is more obvious in the Yangtze River Delta, Beijing-Tianjin-Hebei, and other developed urban agglomerations in the east. Therefore, the government can accelerate the development of the digital economy, active regional innovation, and entrepreneurship activities so as to find a way to promote the sustainable development of enterprises.
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