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This study aimed to explore the mechanism of college students’ meaning of life. The Emotion Regulation Questionnaire, the Gratitude Questionnaire Six-Item Form, the General Wellbeing Schedule, the Meaning in Life Questionnaire were used as measurement instruments. In total, 1,312 valid responses were obtained. The results showed that the cognitive reappraisal and expression suppression strategies were significantly positively and negatively correlated with gratitude, subjective wellbeing, and the sense of life meaning, respectively. Further, Emotion regulation strategies can affect college students’ sense of life meaning through three paths: the mediating effect of gratitude; the mediating effect of subjective wellbeing; the chain mediating effect of gratitude and subjective wellbeing. This study illuminated the roles of gratitude, and subjective wellbeing in influencing the sense of life meaning among the Chinese college students. Limitations and future research directions are discussed.

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