PurposeBreast cancer (BC) has been extensively and deeply studied as the number one malignant tumor in women, but its status in male patients, especially in male metastatic patients, is rarely reported. Thus, this study aimed to explore the prognosis and risk factors of male BC with bone metastasis.Patients and MethodsWe searched the Surveillance, Epidemiology, and End Results (SEER) database to identify all patients diagnosed with male BC with bone metastasis from 2010 to 2016. Risk factors of overall survival (OS) and cancer-specific survival (CSS) were analyzed by univariable and multivariable Cox analyses. We also drew Kaplan–Meier plots to show the correlation between independent risk factors and survival.ResultsA total of 207 male BC patients with bone metastasis were included for analysis. Approximately one-third of patients also had lung metastasis. Luminal A subtype comprised 58.5% of the overall patient population. These patients had a poor prognosis, with 3-year OS and CSS rates, 36.7% and 39.5%, respectively. Further analysis revealed that age ≤60 years old, luminal A or B, and surgery were independent predictors of prolonged OS and CSS. On Cox multivariable analysis, brain metastasis was associated with OS and not CSS.ConclusionWe identified four independent factors associated with prognosis in male BC patients with bone metastasis, namely age, tumor subtype, surgery, and brain metastasis. Knowing these risk factors will help clinicians make more appropriate treatment plans.
Proximal fibula osteotomy (PFO) is a relatively new surgery to treat medial compartment knee osteoarthritis (KOA), which can improve varum deformity and relieve knee joint pain. However, the gait alterations in KOA patients after PFO are still poorly understood. The purpose of this study was to evaluate the gait patterns change in patients of medial compartment KOA after PFO. Gait data were collected for 9 females with unilateral medial compartment KOA before and at 6 months after PFO and also for 9 healthy age-matched females. Paired t -test was used to determine the effect of PFO within the KOA group, and independent t -test were performed to compare between KOA and control groups for spatiotemporal, kinematic, and kinetic variables. The results showed that patients with KOA had significantly increased knee peak flexion angle, knee sagittal range of motion, and peak external hip adduction moment but decreased knee frontal range of motion in the affected limb after PFO. The gait symmetry was improved postoperatively confirmed by single support and swing phases, knee peak flexion angle and sagittal range of motion, peak external hip and knee adduction moments, and peak anterior and peak posterior ground reaction forces. These findings provided evidence of a biomechanical benefit and gait improvement following PFO to treat medial compartment KOA.
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