The ETS protein PEA3 functions as a transcription factor to regulate gene expression. Although members of the ETS family have been reported to be involved in tumor progression, ectopic expression of PEA3 has been shown to suppress tumor formation. Despite several studies demonstrated frequent expression of PEA3 and its high association with HER-2/neu and have suggested a potential role of PEA3 in breast cancer, contradictory result has shown that the PEA3 was associated with better survival rate in breast cancer. In the current study, we address this discrepancy by examining the expression of PEA3 and HER-2/neu on 289 archived breast cancer tumor tissues and their correlation with clinicopathologic factors and prognosis. The staining of PEA3 was further validated by in situ hybridization for PEA3 mRNA. We found PEA3 was positive in 22.2% (64/289) of all cases and only 25.6% (21/82) of HER-2/neu-overexpressing cases showed co-expression of PEA3. In contrast to HER-2/neu, PEA3 expression was not correlated with prognosis or major clinicopathologic factors, except for a negative correlation with lymphovascular permeation ( p=0.007). This study demonstrates that PEA3 expression is not correlated with HER-2/neu expression in breast cancer tumor tissues, nor is it associated with adverse clinicopathologic factors or prognosis.
Using AgNO 3 as the Ag source, the Ag@BiOCl photocatalyst was prepared by depositing noble metal Ag on the surface of BiOCl by solvothermal method. Ag exists as spherical particles with a diameter of 40 nm. Based on the surface plasmon resonance effect (SPR) of Ag, the photoresponse range of BiOCl was successfully extended to the visible light region, which reduced the photo-generated electron-hole recombination e ciency and improved the charge transfer e ciency. The photocatalytic performance of Ag@BiOCl was studied under visible light. The results show that when the Ag content is 10wt%, it exhibits excellent effects on the degradation of acid red B (ARB), and its degradation rate constant is 11 times larger than that of BiOCl. The active substance-capturing test results show that the main role in photocatalytic degradation of ARB is voids.
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