The Maximum k-Defective Clique Problem (MDCP), as a clique relaxation model, has been used to solve various problems. Because it is a hard computational task, previous works can hardly solve the MDCP for massive sparse graphs derived from real-world applications. In this work, we propose a novel branch-and-bound algorithm to solve the MDCP based on several new techniques. First, we propose two new upper bounds of the MDCP as well as corresponding reduction rules to remove redundant vertices and edges. The proposed reduction rules are particularly useful for massive graphs. Second, we present another new upper bound by counting missing edges between fixed vertices and an unfixed vertex for cutting branches. We perform extensive computational experiments to evaluate our algorithm. Experimental results show that our reduction rules are very effective for removing redundant vertices and edges so that graphs are reduced greatly. Also, our algorithm can solve benchmark instances efficiently, and it has significantly better performance than state-of-the-art algorithms.
Variational Bayes (VB) is a popular tool for Bayesian inference in statistical modeling. Recently, some VB algorithms are proposed to handle intractable likelihoods with applications such as approximate Bayesian computation. In this paper, we propose several unbiased estimators based on multilevel Monte Carlo (MLMC) for the gradient of Kullback-Leibler divergence between the posterior distribution and the variational distribution when the likelihood is intractable, but can be estimated unbiasedly. The new VB algorithm differs from the VB algorithms in the literature which usually render biased gradient estimators. Moreover, we incorporate randomized quasi-Monte Carlo (RQMC) sampling within the MLMC-based gradient estimators, which was known to provide a favorable rate of convergence in numerical integration. Theoretical guarantees for RQMC are provided in this new setting. Numerical experiments show that using RQMC in MLMC greatly speeds up the VB algorithm, and finds a better parameter value than some existing competitors do.
We collaborate with a large teaching hospital in Shenzhen, China and build a high-fidelity simulation model for its ultrasound center to predict key performance metrics, including the distributions of queue length, waiting time and sojourn time, with high accuracy. The key challenge to build an accurate simulation model is to understanding the complicated patient routing at the ultrasound center. To address the issue, we propose a novel two-level routing component to the queueing network model. We apply machine learning tools to calibrate the key components of the queueing model from data with enhanced accuracy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.