The Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction to synthesize alkynyl ketones from terminal alkynes and aryl iodides was achieved by using water as a solvent. The reaction was carried out at room temperature under balloon pressure of CO with Et(3)N as a base. The developed method was successfully applied to the synthesis of flavones.
[reaction: see text] Design and synthesis of a novel family of furancarbothioamide-based palladacycles are reported herein. These palladacycles are thermally stable, not sensitive to air or moisture, and are applied effectively in the Heck reaction of aryl halides with terminal olefins and in the Suzuki reaction of aryl halides with arylboronic acids. These reactions were performed under aerobic conditions, leading to turnover numbers (TONs) up to 1 x 10(5).
Ketones Q 0350Pd-Catalyzed Copper-Free Carbonylative Sonogashira Reaction of Aryl Iodides with Alkynes for the Synthesis of Alkynyl Ketones and Flavones by Using Water as a Solvent. -(LIANG, B.; HUANG, M.; YOU, Z.; XIONG, Z.; LU, K.; FATHI, R.; CHEN*, J.; YANG, Z.; J. Org. Chem. 70 (2005) 15, 6097-6100; Key Lab. Bioorg.
The radical hydrostannation of 1-alkynylphosphonates gives the (Z)-α-stannyl-1-alkenylphosphonates 2 stereoselectively; 2 can be transformed into α-iodo-1-alkenylphosphonates and α-substituted vinylphosphonates with retention of configuration.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.