The accurate diagnosis of Alzheimer's disease (AD) and its early stage, i.e., mild cognitive impairment, is essential for timely treatment and possible delay of AD. Fusion of multimodal neuroimaging data, such as magnetic resonance imaging (MRI) and positron emission tomography (PET), has shown its effectiveness for AD diagnosis. The deep polynomial networks (DPN) is a recently proposed deep learning algorithm, which performs well on both large-scale and small-size datasets. In this study, a multimodal stacked DPN (MM-SDPN) algorithm, which MM-SDPN consists of two-stage SDPNs, is proposed to fuse and learn feature representation from multimodal neuroimaging data for AD diagnosis. Specifically speaking, two SDPNs are first used to learn high-level features of MRI and PET, respectively, which are then fed to another SDPN to fuse multimodal neuroimaging information. The proposed MM-SDPN algorithm is applied to the ADNI dataset to conduct both binary classification and multiclass classification tasks. Experimental results indicate that MM-SDPN is superior over the state-of-the-art multimodal feature-learning-based algorithms for AD diagnosis.

The experimental results indicate that the proposed DCCA-MKL framework achieves best performance for discriminating benign liver tumors from malignant liver cancers. Moreover, it is also proved that the three-phase CEUS image based CAD is feasible for liver tumors with the proposed DCCA-MKL framework.

High availability is the most important and challenging problem for cloud providers. However, virtual machine monitor (VMM), a crucial component of the cloud infrastructure, has to be frequently updated and restarted to add security patches and new features, undermining high availability. There are two existing live update methods to improve the cloud availability: kernel live patching and Virtual Machine (VM) live migration. However, they both have serious drawbacks that impair their usefulness in the large cloud infrastructure: kernel live patching cannot handle complex changes (e.g., changes to persistent data structures); and VM live migration may incur unacceptably long delays when migrating millions of VMs in the whole cloud, for example, to deploy urgent security patches. In this paper, we propose a new method, VMM live upgrade, that can promptly upgrade the whole VMM (KVM & QEMU) without interrupting customer VMs. Timely upgrade of the VMM is essential to the cloud because it is both the main attack surface of malicious VMs and the component to integrate new features. We have built a VMM live upgrade system called Orthus. Orthus features three key techniques: dual KVM, VM grafting, and device handover. Together, they enable the cloud provider to load an upgraded KVM instance while the original one is running and "cut-and-paste" the VM to this new instance. In addition, Orthus can seamlessly

Summary When facing massive statistical data, the k‐means algorithm is very difficult to satisfy the need of data processing as it lacks an effective parallel mechanism. This paper proposes an improved k‐means algorithm (IMR‐KCA) to conduct clustering analysis based on medical data employing MapReduce computing framework. Through analyzing the defects of vast redundancy in the traditional k‐means algorithms, a selection model is firstly proposed to simplify the computations with multiple clustering centers. Based on several proposed theorems, we prove the correctness of this selection model. Second, this paper provides a method to calculate the distances from extreme points to central points, and the original Euclidean distance is replaced with Manhattan distance. For this simplification, a group of theorems are proposed to prove the correctness. Next, we provide a group of implementation algorithms to complete the parallelism of the clustering computation employing the MapReduce framework. Finally, the experimental results illustrate that IMR‐KCA is more reliable and efficient than the direct parallelization of the traditional clustering algorithms based on MapReduce. Copyright © 2017 John Wiley & Sons, Ltd.

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