Tumor-targeted magnetic hyperthermia has recently attracted much attention. Magnetic nanoparticles (NPs) are heat mediator nanoprobes in magnetic hyperthermia for cancer treatment. In this paper, single cubic spinel structural Zn0.3Fe2.7O4 magnetic NPs with sizes of 14 nm–20 nm were synthesized, followed by coating with SiO2 shell. The SLP value of Zn0.3Fe2.7O4/SiO2 NPs below 20 nm changes non-monotonically with the concentration of solution under the alternating current (AC) magnetic field of 430 kHz and 27 kA/m. SLP values of all Zn0.3Fe2.7O4/SiO2 NPs appear a peak value with change of solution concentration. The solution concentrations with optimal SLP value decrease with increasing magnetic core size. This work can give guidance to the better prediction and control of the magnetic hyperthermia performance of materials in clinical applications.
High quality Zn0.5Co
x
Fe2.5 – x
O4 (x = 0, 0.05, 0.1, 0.15) serial magnetic nanoparticles with single cubic structures were prepared by the modified thermal decomposition method, and Zn0.5Co
x
Fe2.5 – x
O4/SiO2 composite magnetic nanoparticles were prepared by surface modification of SiO2. The magnetic anisotropy of the sample increases with the increase of the doping amount of Co2+. When the doping amount is 0.1, the sample shows the transition from superparamagnetism to ferrimagnetism at room temperature. In the Zn0.5Co
x
Fe2.5 – x
O4/SiO2 serial samples, the maximum value of specific loss power (SLP) with 1974 W/gmetal can also be found at doping amount of x = 0.1. The composite nanoparticles are expected to be an excellent candidate for clinical magnetic hyperthermia.
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