Purpose: In our study, we aimed to evaluate the role of postoperative radiotherapy for patents with de novo stage IV breast cancer.Patients and Methods: Patients diagnosed with stage IV breast cancer from 2010 to 2016 were selected from the Surveillance, Epidemiology, and End Result (SEER) database. Those patients who received both chemotherapy and surgery and lived longer than 6 months were divided into radiotherapy and non-radiotherapy groups. Kaplan-Meier analysis and multivariate Cox proportional hazards models were used to estimate the survival outcomes before and after being 1:1 propensity score matched (PSM). Subgroup analyses stratified by age, subtype, status of distant metastasis, and surgery type were also performed.Results: Among 1,935 patients, 52% (1006) underwent radiotherapy while the non-radiotherapy group contained 48% (929). After PSM, a total of 1,520 patients in two groups of 760 patients were enrolled in this analysis. Kaplan-Meier and the multivariate survival analysis demonstrated that the radiotherapy group presented with a better prognosis compared to the non-radiotherapy group (after PSM, BCSS: Hazard Ratio, 0.697; 95% confidence interval, 0.59–0.823; P < 0.001; OS: Hazard Ratio, 0.707; 95% confidence interval, 0.601–0.831; P < 0.001). Further subgroup analyses showed the Luminal subtype (HR+/HER2–), triple-negative breast cancer (TNBC), and bone-only metastasis patients presented with the most promising survival in the radiotherapy group.Conclusions: Postoperative radiotherapy is associated with a significant survival advantages in BCSS and OS. It can be an optimal supplementary treatment for stage IV patients after surgery, especially for Luminal subtype, TNBC, and patients with a low metastatic burden.

Purpose: To investigate the application value, feasibility and safety of modified single-port laparoscopic surgery in the treatment for inguinal hernia in children. Methods: 60 cases of children with indirect inguinal hernia admitted from 2019 to 2022 were divided into control group and observation group, with 30 cases in each group. They underwent traditional open high ligation of hernia sac and modified single-port laparoscopic high ligation of hernia sac, respectively. The operation duration, surgical incision size, intraoperative blood loss, postoperative hospital stay, first ambulation time, hospitalization expenses were compared between the two groups, as well as the incidence of surgical complications in two groups. Results: The surgical incision size, intraoperative blood loss, postoperative hospital stay, and first ambulation time of observation group were less than those of control group. There was no significant difference in operation duration or hospitalization expenses between the two groups. Only 1 case in observation group showed suture knot reaction after surgery, with no incision infection, inguinal hematoma, iatrogenic cryptorchidism, etc. The overall incidence of complications in observation group was lower than that of control group. Conclusion: The modified single-port laparoscopic surgery for inguinal hernia in children has the advantages of minimal invasiveness, enhanced recovery, less complications and recurrence, thus should be recommended in clinical application.