Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians. We identified 11 independent loci associated with longevity replicated in Southern-Northern regions of China, including two novel loci (rs2069837-IL6; rs2440012-ANKRD20A9P) with genome-wide significance and the rest with suggestive significance (P < 3.65 × 10−5). Eight independent SNPs overlapped across Han Chinese, European and U.S. populations, and APOE and 5q33.3 were replicated as longevity loci. Integrated analysis indicates four pathways (starch, sucrose and xenobiotic metabolism; immune response and inflammation; MAPK; calcium signaling) highly associated with longevity (P ≤ 0.006) in Han Chinese. The association with longevity of three of these four pathways (MAPK; immunity; calcium signaling) is supported by findings in other human cohorts. Our novel finding on the association of starch, sucrose and xenobiotic metabolism pathway with longevity is consistent with the previous results from Drosophilia. This study suggests protective mechanisms including immunity and nutrient metabolism and their interactions with environmental stress play key roles in human longevity.

A novel magnetorheological (MR) damper with a multistage piston and independent input currents is designed and analyzed. The equivalent magnetic circuit model is investigated along with the relation between magnetic induction density in the working gap and input currents of the electromagnetic coils. Finite element method (FEM) is used to analyze the distribution of magnetic field through the MR fluid region. Considering the real situation, coupling equations are presented to analyze the electromagneticthermal-flow coupling problems. Software COMSOL is used to analyze the multiphysics, that is, electromagnetic, thermal dynamic, and fluid mechanic. A measurement index involving total damping force, dynamic range, and induction time needed for magnetic coil is put forward to evaluate the performance of the novel multistage MR damper. The simulation results show that it is promising for applications under high velocity and works better when more electromagnetic coils are applied with input currents separately. Besides, in order to reduce energy consumption, it is recommended to apply more electromagnetic coils with relative low currents based on the analysis of pressure drop along the annular gap.

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Magnetorheological dampers have been widely studied as versatile real-time actuators for solving vibration problems in various structures and systems. However, the inherent time delay problem of magnetorheological actuators may cause performance degradation of semi-active control systems. The primary purposes of this article are to provide a comprehensive analysis on the time delay of an impact buffer system based on a magnetorheological damper and to propose compensation methods to reduce the time delay. To this end, this study evaluated the electromagnetic circuit in the magnetorheological damper and designed an advanced correcting circuit to improve the response time. The simulation results show that the proposed circuit reduces the time delay by 5 ms. Using a magnetorheological buffer system setup, its force response times were tested. The experimental results show that the electromagnetic circuit plays a significant role in the time delay and it is highly dependent on the effectiveness of the electric parts of the control hardware. Furthermore, a proportional-integral-derivative controller is able to reduce the time delay and improve the dynamic performance of the magnetorheological impact buffer system.