INTRODUCTION: Blood metabolomics-based biomarkers may be useful to predict measures of neurocognitive aging. METHODS: We tested the association between 707 blood metabolites measured in 1,451 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), with MCI and global cognitive change assessed seven years later. We further used Lasso penalized regression to construct a metabolomics risk score (MRS) that predicts MCI, potentially identifying a different set of metabolites than those discovered in individual-metabolite analysis. RESULTS: We identified 20 metabolites associated with MCI and/or global cognitive change. Six of them were novel and 14 were previously reported as associated with neurocognitive aging outcomes. The MCI MRS comprised 61 metabolites and improved prediction accuracy from 84% (minimally adjusted model) to 89% in the entire dataset and from 75% to 87% among APOE-ε4 carriers. Conclusions: Blood metabolites may serve as biomarkers identifying individuals at risk for MCI among U.S. Hispanics/Latinos.
Adiposity has been linked with mortality among Whites/Asians, but evidence from Hispanics is limited. We included 15855 adults from the Hispanic Community Health Study/Study of Latinos (2008-11). BMI, waist circumference (WC), waist-to-hip ratio (WHR), and body fat percentage (BF%) were measured, and Cox regressions estimated their relations with mortality. Over 153828 person years (median 10 years), 651 deaths occurred. With adjustment of sociodemographic and lifestyle covariates (Figure; Model 1), no dose-response relation of BMI or BF% with mortality was found. Compared with normal weight (BMI<25 kg/m2), only severe obesity (BMI≥35 kg/m2) was associated with higher mortality (HR=1.58, 95% CI 1.08-2.31). Central obesity was associated with higher mortality with HRs (95% CIs) of 1.41 (1.01-1.97) comparing WC of >102/88 cm (for men/women) vs ≤94/80 cm and 1.70 (1.14-2.53) comparing WHR of ≥0.90/0.85 vs <0.90/0.85. With further adjustment of baseline comorbidities (Figure; Model 2), only WHR remained associated with mortality. BMI was highly correlated with BF% and WC (r>0.84) but not WHR (r=0.54). WHR remained associated with mortality after further adjusting for BMI. Sex suggestively modified the relation of WHR with mortality which was stronger among women. Among US Hispanic/Latino adults, only severe obesity was associated with higher mortality. WHR could predict mortality better and should be evaluated in bodyweight management. Disclosure Y.Zhang: None. R.Kaplan: None. Q.Qi: None. G.Chen: None. D.Sotres-alvarez: None. K.M.Perreira: None. L.Gallo: None. M.M.Llabre: None. J.Cai: None. X.Xue: None. C.R.Isasi: None. Funding National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119268, R01DK120870, P30DK111022); National Heart, Lung, and Blood Institute (HHSN268201300001I/N01-HC-65233, HHSN268201300004I/N01-HC-65234, HHSN268201300002I/N01-HC-65235, HHSN268201300003I/N01-HC-65236, HHSN268201300005I/N01-HC-65237)
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