В статье приводится анализ динамики иммунологической реактивности у больных двух клинических групп, в которые включены 40 пациентов с паховыми грыжами, которым произведены ауто-и аллопластический метод герниопластики при паховых грыжах. Динамика иммунологической реактивности была изучена при помощи определения уровня субпопуляции лимфоцитов с рецепторами CD3, CD4, CD8, CD20, интерлейкин 6, интерлейкин 10, иммуноглобулины A, M, G. В ходе сравнения полученных результатов исследования отмечено, что в группе аллопластических методов герниопластики в послеоперационном периоде достоверно отличались от исходного в сторону незначительного повышения. Содержание лейкоцитов составило 4,
The article presents the results of surgical treatment of bleeding from esophageal and gastric varices in patients with sub- and decompensated hepatic cirrhosis. The study included 62 patients. The average age was 46.7±15.2 years. The vast majority of patients had clinical signs of severe hepatic failure in accordance with the Child-Pugh criteria (class B — 24, class C — 38 patients). Among the patients, two groups were identified. In the control group, 20 patients underwent suturing of varicose veins (operation by M. D. Patsiora) due to the failure of conservative treatment. In the main group, 42 patients were operated on in a combined way in the early stages from the moment of admission. The results obtained indicated an increase in the survival rate of patients in the stage of sub- and decompensation, operated on in the early stages and by the proposed combined method.
The article analyzes the review of the literature of foreign authors and authors of the CIS countries on the immunological response to the used mesh endoprostheses in patients after alloplastic methods of hernioplasty with hernias of the anterior abdominal wall. Currently, it is possible to monitor the course of the wound process in patients operated on for hernia using the immunological method. The correlation dependence of the nature of complications in the wound with indicators of additional research methods has not been sufficiently studied, which requires further study of this issue.
In the length of time, a wide variety of drug combinations emerged in the management of post-transplantation therapy in order to improve the survival of the recipient and graft. However, the efficacy and safety of the applied combinations regarding the rejection and other complications are continuing to be the subject of research. In our study, our aim is to compare the effects of various combinations, namely cyclosporine with mycophenolate mofetil/mofetil mycophenolic acid with prednisolone and tacrolimus with mycophenolate mofetil/mofetil mycophenolic acid with prednisolone in a length of time. Methods. A total of 204 patients included into the study who received post-renal transplantation treatment in Scientific-Research Institute of Heart Surgery and Organs Transplantation and followed-up over a 10-year period. The estimated survival probabilities in the study were determined by the Kaplan-Meier method; whereas intragroup comparisons were evaluated by Log-rang, Breslow, and Tarone-Ware tests. Complications occurred in patients with combinations were analyzed by Chi-square and its alternatives. Hazard risk factors were tested by Cox regression analysis. Results. Of these 204 patients, 36 received Cyclosporin combination (CCG) and 168 Tacrolimus combination (TCG). The estimated life expectancy of the patients of TCG was significantly longer than the CCG ones. Furthermore, gender and age did not have a significant effect on survival depending on time, however, gender and age-related hazard factor showed a significant difference in the groups. It was determined that chronic rejection was significantly different in patients who used tacrolimus combinations, the difference was close to the significant value in acute rejection analysis. Other adverse events, namely, infection, tumour and organ damage were statistically less common in the patient group treated with tacrolimus combinations. Conclusion. In general, TCG showed better results in contrast to CCG.
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