Objective: Iron deficiency is the most common etiological cause of anemia in premenopausal patients and characterized with hypochromic, microcytic erythrocytes. Iron deficiency anemia (IDA) has been reported to accompany the changes in both the count and the parameters of platelets (PLT). In our study, we evaluated possible PLT changes by complete blood count (CBC) and anemia tests conducted on women aged between 15 and 48 who were diagnosed with IDA before and after iron replacement treatment.Methods: Ninety-six patients with the diagnosis of IDA were included in our study. Iron (Fe), total iron-binding capacity (TIBC), ferritin, hemoglobin (HGB), hematokrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red cell distribution volume (RDW) levels, and PLT counts of the patients before and after the treatment were compared. In this comparison, Wilcoxon test and for the relationship between the variables Pearson correlation analysis were used. A p value of <0.05 was considered to be statistically significant.Results: Ferritin, Fe, HGB, HCT, MCV, and MCH levels after the treatment were found to be significantly increased (p=0.0001) and UIBC, TIBC, RDW, and PLT were significantly decreased (p=0.0001) when compared with those before the treatment. A negative correlation between PLT and HCT, MCV, and MCH (r=0.216, 0.236, 0.366; p=0.035, 0.021, 0.0001, respectively) and a positive correlation between PLT and RDW (r=0.35 and p=0.0001) was observed.Conclusion: PLT counts of the patients after the treatment were found to be decreased. PLT counts that were increased but in the normal range could be because the hypochromic, microcytic erythrocytes were probably counted as PLT on automated blood count analyzers and/or because of increased erythropoietin (EPO) in IDA. (JAREM 2015; 5: 94-6)
ÖZETAmaç: Kronik viral C hepatiti başta olmak üzere bazı hastalıklarda interferon-alfa tedavisi sırasında otoimmün tiroidit insidansının arttığı bilinmektedir. Ancak bazı çalışmalarda otoimmün tiroidit olgularında, interferon-alfa tedavisinden bağımsız, viral hepatit birlikteliği bildirilmiştir. Çalışmamızda Hashimoto Tiroiditi ile birlikte Hepatit B (HBV) ve Hepatit C (HCV) enfeksiyonu görülme insidansını araştırmak istedik.Yöntemler: G.O.P Taksim Eğitim ve Araştırma Hastanesi'nde yeni tanı almış Hashimoto Tiroiditli 228 kadın, 31 erkek toplam 259 hastanın serumlarında eş zamanlı bakılan viral hepatit belirleyicileri ve tiroid otoantikorları verileri hastane laboratuvar bilgi yönetim sistemi arşivinden retrospektif taranarak kaydedildi.Bulgular: Çalışma verileri incelendiğinde 1 hastanın HBs Ag (+), anti HBs (-), HBe Ag (-), AST ve ALT normal sınırlarda aktif viral hepatiti olmayan HBV taşıyıcısı olduğu saptandı. 28 hasta HBs Ag (-), anti HBs (+); HBV'üne karşı aşılıydı. Tüm hastalar anti-HCV (-) saptandı.Sonuç: Çalışmamızda Hashimoto Tiroiditi tanısı alan hasta grubunda aktif viral hepatit varlığına rastlayamadık. Genetik yatkınlığı olan bireylerde çevresel faktörlerin tiroid otoimmünitesini tetiklediğini gösteren birçok çalışma bulunmaktadır. Çalışmamıza dahil edilen hastaların genetik predispozisyonları açısından incelenmesi Hashimoto Tiroiditi etyolojisinde viral hepatitlerin rolünü aydınlatması açısından yararlı olabilir. (JAREM 2014; 2: 52-4) Anahtar Sözcükler: Viral hepatit, otoimmün tiroid hastalığı, Hashimoto tiroiditi ABSTRACT Objective: During interferon-alpha treatment of mainly chronic viral hepatitis C (HCV), the incidence of autoimmune thyroiditis increases. However, in some studies, autoimmune thyroiditis could be found together with viral hepatitis independently from interferon-alpha treatment. In our study, we investigated the concomitance of Hashimoto thyroiditis with hepatitis B (HBV) and/or HCV infections.Methods: A total of 259 newly diagnosed patients with Hashimoto's thyroiditis, comprising 228 woman and 31 men, were included in our study. The simultaneously analyzed thyroid auto-antibodies and viral hepatitis markers were scanned retrospectively from our LIS (Laboratory Information System) archive. Results:Our data have shown only 1 patient was an HBV carrier without active hepatitis; 28 patients were observed to be immunized with HBV, and all patients were found to be HCV (-). Conclusion
Objective: Vitamin B 12 (cyanocobalamin) is a water soluble hematopoietic vitamin that functions in somatic cell metabolism. Vitamin B 12 is commonly measured by direct chemiluminescence immunoassay methods in routine biochemistry laboratories. Serum samples to be tested for vitamin B 12 are recommended to be kept protected from light. On the basis of this information, we aimed to evaluate the effect of light and waiting time till analysis on vitamin B 12 tests.Methods: In total, 52 volunteers (27 women and 25 men) were included in our study. To prevent the effect of light, we prepared darkened tubes for blood collection. Simultaneously, two tubes of blood samples (one darkened and one normal) were drawn from each patient. The measurements were performed on the 0 th and 12 th hours using the Roche Hitachi Modular E 170 autoanalyser. The Mann-Whitney U test and Wilcoxon test were used, and p<0.05 was considered significant.Results: There were no significant differences in vitamin B 12 levels between darkened and normal tubes on the 0 th and 12 th hours (p>0.05). In comparison with the baseline (0 th hour), the percentage difference in darkened tubes were found to be significantly decreased on the 12 th hour (p<0.05).
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