Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma. As the symptoms of patients with early renal clear cell carcinoma are not obvious, the appearance of obvious symptoms means that the tumor is already at an advanced stage. The 5-year survival rate is only 5-10%. It is necessary to discern novel biomarkers and targets for the diagnosis, treatment and prognosis of ccRCC. G protein-coupled receptor kinase 6(GRK6) is closely related with clear cell renal cell carcinoma. Therefore, GRK6 is the focus of our research.Methods:The sequencing date from the Cancer Genome Atlas database and Gene Expression Omnibus were used to analyze GRK6 expression and gene regulation networks in expression of GRK6 and used cBioPortal to identify GRK6 alterations and related functional analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. The target networks of kinases, miRNAs and transcription factors were examined by Gene enrichment analysis.Results: Eventually, we found that GRK6 is overexpressed and amplification is the most common type of GRK6 CNV in ccRcc. The functional networks of GRK6 is in connection with cytokine metabolic process, chemokine regulation,interferon-gamma production and adaptive immune response. Functional network analysis suggested that GRK6 regulates proteasome, ribosome, base excision repair, DNA replication, RNA splicing and protein translation via pathways involving multiple tumor-associated kinases, miRNAs and transcription factors.Conclusions: The results show that data mining efficiently reveals information about GRK6 expression and potential networks in ccRcc, and it lays a solid foundation for future research of the role of GRK6 in carcinogenesis.
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