The records of all patients with orbital cavernous hemangioma managed at Zhongshan Ophthalmic Center, Sun Yat-sen University from Jan. 1, 1986 to Dec. 31, 2000 (n = 214) were reviewed retrospectively. Among them, 126 patients were female and 88 were male. The mean age was 39.4 years, ranging from 5.0 to 68.0 years. The left orbit was affected in 127 cases and the right one in 87 cases. No case showed bilateral involvement. A painless, gradually progressive proptosis and visual disturbance were the main clinical signs. Ninety-three percent of the patients (199/214) could be accurately diagnosed preoperatively based on echography and CT/MRI. The tumors were removed successfully by standard lateral orbitotomy in 35% (75/214) and by anterior orbitotomy in 65% (139/214). Anterior orbitotomy has become an important surgical procedure in the treatment of orbital cavernous hemangioma with excellent effect.

Pediatric IOIP accounted for 11.5% of all IOIP patients. Pediatric cases had more sign of ptosis and less sign of proptosis than in adult IOIP. The full recovery response rate was low in children with IOIP.

Recent studies suggested that gut microbiota was involved in the development of coronary artery disease. However, the changes of gut microbiota following acute myocardial infarction (AMI) remain unknown. In this study, a total of 66 male Wistar rats were randomly divided into control, AMI and SHAM groups. The controls (n = 6) were sacrificed after anesthesia. The AMI model was built by ligation of left anterior descending coronary artery. The rats of AMI and SHAM groups were sacrificed at 12 h, 1 d, 3 d, 7 d and 14 d post-operation respectively. Gut microbiota was analyzed by 16S rDNA high throughput sequencing. The gut barrier injuries were evaluated through histopathology, transmission electron microscope and immunohistochemical staining. The richness of gut microbiota was significantly higher in AMI group than SHAM group at 7 d after AMI (P<0.05). Principal coordinate analysis with unweighted UniFrac distances revealed microbial differences between AMI and SHAM groups at 7 d. The gut barrier impairment was also the most significant at 7 d post-AMI. We further identified the differences of microorganisms between AMI and SHAM group at 7 d. The abundance of Synergistetes phylum, Spirochaetes phylum, Lachnospiraceae family, Syntrophomonadaceae family and Tissierella Soehngenia genus was higher in AMI group compared with SHAM group at 7 d post-operation (q<0.05). Our study showed the changes of gut microbiota at day 7 post AMI which was paralleled with intestinal barrier impairment. We also identified the microbial organisms that contribute most.

Idiopathic orbital inflammatory pseudotumor and lymphoid tumor showed distinguishing clinical, morphologic, immunophenotypic, and molecular genetic characteristics.