To enhance the catalytic activity of the nanozymes for efficient wound healing infected with multidrug‐resistant bacteria, photo‐based motivations have been suggested, but attention is mainly focused on the external stimulus of near‐infrared light, while the inexhaustible visible one is promising but lack of study. Herein, an efficient visible light‐stimulated peroxidase‐like nanozyme system, TiO2 nanotubes coated with MoS2 nanoflowers (TiO2NTs@MoS2), is discovered for efficient bacterial treatment. Based on the synergetic effects between the two components, the bandgap of the TiO2NTs can be narrowed from 3.2 to 2.97 eV due to the MoS2 loading, which extended the light response of TiO2 to visible‐light range and enhanced the photocatalytic activity accordingly. Meanwhile, the peroxidase‐like activity of MoS2 can be significantly enhanced due to the combination with TiO2NTs in return. Especially, the peroxidase‐like activity of the TiO2NTs@MoS2 nanocomposite can be further improved under the sunlight irradiation, rendering much more hydroxyl radical (•OH) generation. Accordingly, the as‐obtained TiO2NTs@MoS2 shows an outstanding antibacterial effect against drug‐resistance extended spectrum β‐lactamases producing Escherichia coli and methicillin‐resistant Staphylococcus aureus under the visible light. In vivo wound healing test further confirms the high antimicrobial efficiency and good biocompatibility of the synergistic antimicrobial system.

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The design and construction of efficient nanozymes are vital for bio/chemo-sensing applications, while the systematic catalytic mechanism study is the prerequisite. Tungsten oxide (WO3–x ) quantum dots (QDs), an alternative to conventional heavy metal-containing semiconductor QDs, possess peroxidase-like activity but limited catalytic efficiency. Therefore, the functions of the typical oxygenous groups in determining the enzymatic activity of the WO3–x QDs by target-specifically shielding the carboxyl (COOH), hydroxyl (OH), or carbonyl (CO) groups, respectively, using a chemical titration method. The results show that the CO groups could accelerate the nanozymatic catalysis kinetically, while the OH ones were the catalytically inhibitive sites, which were further corroborated by the density functional theory (DFT) computations. The application potential of the WO3–x derivatives with an enhanced catalytic ability was verified via the colorimetric cholesterol sensing. The proposed method based on the benzoic anhydride (BA)-modified WO3–x QDs with deactivated OH groups showed a wider linear range and higher sensitivity than those based on the unmodified ones.

Trigeminal neuralgia (TN) is a common facial neuropathic pain that is mainly characterized by spontaneous or induced needling or electric shock pain in the innervation area of the trigeminal nerve. It is also referred to as “the cancer that never dies”. The olfactory ensheathing cell (OEC) is a special glial cell in the nervous system that has a strong supportive function in nerve regeneration. Cell transplantation therapy is a useful treatment modality that we believe can be applied in TN management. In this study, OECs were transplanted into the ligation site of the infraorbital nerve of rats. We found that after the OEC transplantation, mechanical pain threshold in the face of the rats was significantly increased. Western blotting, immunofluorescence assay, and reverse transcription-quantitative polymerase chain reaction were performed on the trigeminal ganglia (TG) of model rats. The results revealed a decrease in the expression of P2X7 receptor (P2X7R) in the trigeminal ganglia. Our findings show that OEC transplantation has a good therapeutic effect on TN in rats, and that can reduce the expression of P2X7R in trigeminal ganglia. Therefore, we think that OEC transplantation may be a suitable treatment for TN.