Twelve novel compounds of 2-acetyl-1H-benzimidazole oxime-ethers and 2-acetyl-6-chloro-1H-benzimidazole oxime-ethers were synthesized with o-phenylenediamine (or 4-chloro-o-phenylenediamine), 2-hydroxypropyl acid, alkoxy (or benzyloxy) amines hydrochloride as starting materials. The structures of the target compounds were characterized by IR, 1 H NMR spectra and elemental analyses. The in vitro fungicidal activities against Botrytis cinerea Pers and Alternaria alternata were also evaluated by mycelium growth rate method. The results indicate that the compounds 3b, 3c, 3f, 3g and 3h exhibit good activities against Botrytis cinerea Pers, while 3b and 3f possess excellent activities against Alternaria alternate, and their fungicidal activities are all higher than that of carbendazim.
Eighteen novel compounds of 2,5-disubstituted-1,3,4-oxadiazoles containing benzimidazole moiety were synthesized from 1H-benzimidazole-2-carbohydrazide, carbon disul de and alkyl halide or benzyl halide by multi-step reactions. e structures of the target compounds were conrmed by IR, 1 H-NMR spectra and elemental analyses. Preliminary antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum were also evaluated by the mycelium growth rate method, and the results indicated that many target compounds possess excellent antifungal activity, even higher than the control fungicide (carbendazim).
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