The complex [RuCp(PPh3)2(HdmoPTA)](OSO2CF3)2 (2; HdmoPTA = 3,7-H-3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane) was synthesized and characterized. Its crystal structure was determined by single-crystal X-ray diffraction. The complex showed a more potent antiproliferative activity than cisplatin against a representative panel of human cancer cells.

Synthesis, characterization and the antiproliferative activity of a new bimetallic complex [RuCp(PPh)-μ-dmoPTA-1κP:2kN,N'-CoCl]OTf·0.25HO are described. The stability of the complex was studied under air and N atmospheres and in CDCl, DMSO, water and the cell culture medium, at room temperature and 40 °C. The complex showed an enhanced antiproliferative activity (up to six-fold) when compared with its parent complex [RuCp(PPh)(HdmoPTA)] against human lung, cervix, breast, and colon solid tumor cell lines.

The synthesis, characterization and antiproliferative activity of the bimetallic Ru-Zn complex [RuCp(PPh 3 ) 2 -μ-dmoPTA-1κP:2κ 2 N,N′-ZnCl 2 ](CF 3 SO 3 ) (4) and the monometallic Ru complex [RuCp(PPh 3 ) 2 (dmoPTA-1κP)](CF 3 SO 3 ) (5) are presented. Against human lung, cervix, breast, and colon solid tumor cell lines, complex 4 showed an enhanced antiproliferative activity (GI 50 = 30-83 nM) when compared to its parent complex [a]