In general, it has been revealed that interaction of bone substitute material with the host immune system is dependent upon their physico-chemical properties. In the case of xeno-grafts, different purification methods are applied to process the precursor tissue. One purification method that differs the most is the applied temperature. Materials treated with low and high temperatures are available. In this context, the question remains as to the influence of the different temperature treatments on the physical and chemical material properties and, thus, on the tissue reactions during the healing processes. It has been hypothesized that materials that induce mononuclear cells induce physiological healing processes, while a pathological reaction is accompanied with the induction of multinucleated giant cells (MNGCs). In this mini-review, the focus is on the comparison of preclinical research into tissue reactions to sintered and non-sintered bovinederived xenograft. Interpretation of this data showed that an induction of higher numbers of MNGCs by sintered xenograft also induced a higher implant bed vascu-larization. Finally, the higher number of MNGCs and increased vascularization presumably resulted in a higher expression of anti-inflammatory molecules that may support the process of bone remodeling.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.