The effect of fillers and lubricants on the dissolution rate of acetylsalicylic acid (ASA) from matrix tablets has been evaluated. Eudragit S-I00 and Eudragit L-I 00-55 where chosen as matrix substances. The process of drug release in vitro was studied by the modijied halfchange method. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Differences in release rate of ASA from matrix tablets, regarding the diluents used, appeared to be more significant when matrices contained Eudragit L-I 00-55 as compared to Eudragit S-100. The highest dissolution rates of ASA were observed in the presence of Lubritab as lubricant. m e other lubricants used showed similar effects on the release rate of ASA. The release of ASA from samples containing Eudragit L-100-55 corresponded best to the zero-order kinetics. The best-fitted model for the ASA release from tablets prepared with Eudragit S-100 was obtained by using the Hixson-Crowell equation.Compressed matrices with dispersed active agent are the simplest approach in modified release form formulation. Acrylic polymers may be used as the basis for compressed matrices.Many authors have described the prolonged release from acrylic polymer matrices (1-5).
The most important and commonly used process for biodiesel synthesis is transesterification. The main by-product of biodiesel synthesis by transesterification is glycerol, which must be removed from the final product. Recently, deep eutectic solvent (DES) assisted extraction has been shown to be an effective and sustainable method for biodiesel purification. In this study, biodiesel was produced by lipase-catalysed transesterification from sunflower oil and methanol. A total of 12 different eutectic solvents were prepared and their physical properties were determined. Mathematical models were used to define which physical and chemical properties of DES and to what extent affect the efficiency of extraction of glycerol from the biodiesel. After initial screening, cholinium-based DES with ethylene glycol as hydrogen bond donor was selected and used for optimization of extraction process conditions performed in a microsystem. To determine the optimal process conditions (temperature, biodiesel:DES volume ratio, residence time), the experimental three-level-three-factor Box-Behnken experimental design was used. In the end, a combination of a mathematical model and experimental results was used to estimate how many micro-extractors are necessary for the complete removal of glycerol.
The most important and the most used process of biodiesel synthesis is transesterification. The main byproduct formed in the biodiesel synthesis by transesterification is glycerol. Biodiesel produced by transesterification is not suitable for application in engines since it contains soap (if biodiesel is produced by chemical catalysis), traces of the catalyst, methanol, metals, water, oil, and glycerides. All those impurities must be removed in order to reach the standards (ASTM D6751 and EN 14214). The most dominant industrial method for biodiesel purification is wet washing, which generates up to 10 L of wastewater per 1 L of purified biodiesel. Therefore, cheaper and more efficient solutions for biodiesel purification should be found. Deep eutectic solvents (DESs) have been already demonstrated as viable options in biodiesel purification. DESs, a mixture of two or more components with a lower melting point than each individual component, are considered less toxic to the environment, non-volatile, biodegradable, and more stable; in other words, they are economically and environmentally friendly in comparison with organic solvents. In this study, purification of biodiesel produced by lipase catalysed transesterification by DESs was performed by two-phase liquid extraction in a microextractor. A total of 13 different DESs were synthesized and used for biodiesel purification in order to find the one that provides the best glycerol extraction efficiency. After initial screening, three DESs were selected and used for the optimization of process conditions for extraction performed in a microsystem. A three-level-four-factor Box–Behnken experimental design was employed to define the optimal process conditions (biodiesel–DES mass ratio, temperature, residence time). At optimal process conditions, the glycerol content in biodiesel was reduced below 0.02% (w/w), which is the value specified by standards (ASTM D6751 and EN 14214).
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