Renal oncocytoma is a benign renal tumor originated from intercalated cells of collecting ducts like chromophobe renal cell carcinoma (RCC). The differential diagnosis of these 2 tumors is important because while they are histologically and cytologically similar, they show different biological behavior. For the differential diagnosis, several immunohistochemical markers have been investigated. But, differential diagnostic challenges remain and the identification of additional markers is needed. Cytokeratin 7 (CK7) is one of ductal-type keratins, which is expressed in tumors of breast, pancreas, lung, thyroid, ovary, endometrium, urinary bladder, and the kidney. S100A1 is the first defined member of the calcium-binding S100 protein family and it organizes several cellular functions including cell cycle progression and cell differentiation.CD82 is a tetraspanin membrane protein, which functions as a metastasis supressor. In this study, we immunohistochemically investigated the expressions of CK7, S100A1, and CD82 in 30 chromophobe RCC (23 classic and 7 eosinophilic variant) and 19 oncocytomas. When these markers were evaluated separately and together, their expressions in chromophobe RCC and renal oncocytoma show statistically significant difference (P < 0.001). Similar statistically significant results were also seen between eosinophilic chromophobe RCC and oncocytoma (P < 0.001). For both classic and eosinophilic-variant chromophobe RCCs, CK7 + /S100A1 − / CD82 + profile being the most common. In oncocytomas, the most frequently observed profile was CK7 − /S100A1 + /CD82 − . Our results showed that the application of a panel consisting of CK7, S100A1, and CD82 may provide accurate categorization of the tumors in difficult cases.
Hydatid cyst is a parasitic infection caused by Echinococcus granulosus, and is endemic in some countries and regions where the common hosts (cattle, cow, sheep) are frequently raised, such as Middle East, Australia, South America, and Turkey (1). The human is an intermediate host of this parasite, and is usually contaminated through infected foods. Liver and lungs are the most common sites of hydatid cyst whereas soft tissues are rare localizations for this disease, even in endemic areas. Among those, abdominal wall is an extremely unusual site for primary hydatid cyst (1-3). Herein, a rare and interesting case of hydatid cyst located in the anterior abdominal wall was presented.
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