On the African continent, ongoing agriculture intensification is accompanied by the increasing use of pesticides, associated with environmental and public health concerns. Using a systematic literature review, we aimed to map current geographical research hotspots and gaps around environmental and public health risks research of agriculture pesticides in Sub-Saharan Africa (SSA). Studies were included that collected primary data on past and current-used agricultural pesticides and assessed their environmental occurrence, related knowledge, attitude and practice, human exposure, and environmental or public health risks between 2006 and 2021. We identified 391 articles covering 469 study sites in 37 countries in SSA. Five geographical research hotspots were identified: two in South Africa, two in East Africa, and one in West Africa. Despite its ban for agricultural use, organochlorine was the most studied pesticide group (60%; 86% of studies included DDT). Current-used pesticides in agriculture were studied in 54% of the study sites (including insecticides (92%), herbicides (44%), and fungicides (35%)). Environmental samples were collected in 67% of the studies (e.g., water, aquatic species, sediment, agricultural produce, and air). In 38% of the studies, human subjects were investigated. Only few studies had a longitudinal design or assessed pesticide’s environmental risks; human biomarkers; dose-response in human subjects, including children and women; and interventions to reduce pesticide exposure. We established a research database that can help stakeholders to address research gaps, foster research collaboration between environmental and health dimensions, and work towards sustainable and safe agriculture systems in SSA.

In this article the relationship between intergroup contact and racial prejudice in formerly segregated schools in Cape Town, South Africa, is investigated. A total of 1 119 black African, coloured, Afrikaans-speaking and English-speaking white learners were surveyed, using three measures of intergroup prejudice, a self-report intergroup contact measure and a racial identification scale. In general, quality of contact with individuals of other race groups and an increase in contact both in and outside of the school improved learners' race attitudes. Higher levels of demographic integration within schools were also positively related to race attitudes, but a high degree of identification with one's own race led in several instances to less positive attitudes towards other race groups. Intergroup contact seemed to be the single most important predictor of attitudes for all four groups in this study.

International studies have documented the association between poverty, low education levels and poor mental health, including suicide attempts. Many farm worker communities in the Western Cape, South Africa, are exposed to poor living and working conditions throughout their lives. They also tend to suffer from chronic illness such as tuberculosis as well as widespread alcohol abuse. Many farm workers are also exposed to pesticides, which have been associated with affective disorders. Through in-depth, semi-structured interviews this qualitative study explored the life experiences of five suicide survivors and their carers to examine the factors that, according to them, predisposed them to and precipitated the suicide attempt. The impact of the suicide attempt on the familywas also explored as well as shortcomings in terms of psychological support networks in the community. Contextual factors identified by thestudy participants that affected them included abject poverty as a result of unemployment and low education levels, childhood within dysfunctional family environments, early alcohol use and current alcohol dependence, previous and current interpersonal conflict and violence, a sense of hopelessness and the absence of coping mechanisms. Easy access to pesticides as a means for self-harm was also a common factor. Further research on the determinants of suicide attempts in this community is needed, as well as on effective and affordable interventions in remote and vulnerable communities such as these. Addressing structural problems would deal with the underlying reasons for suicidal feelings. In the meantime, shorter-term multisectoral interventions are needed by stakeholders such as government, civil society and faith-based organizations. These could include effective legislation and policies that regulate working and living conditions of farm workers, appropriate mental health care interventions, educational workshops, and nutrition schemes that address the unique needs of rural farming communities.

BackgroundPrevious epidemiological studies investigating modification of organophosphate (OP) neurotoxicity by xenobiotic metabolizing enzymes (XMEs) polymorphisms have produced inconsistent results.MethodsA cross‐sectional study of 301 emerging farmers was conducted. Neurotoxicity testing included forward and backward recall, digit span, and vibration sensitivity testing. Questionnaire data included demography, potential confounders, and work history of pesticide exposures. Genomic DNA was analyzed from study participants for DNA variants of two glutathione S‐transferases (GSTM1 and GSTT1), N‐acetyltransferase 2 (NAT2), and Paraoxonase 1 (PON1).ResultsThere was evidence of OP pesticide neurotoxicity modification by rs1799931 (NAT2), rs662 (PON1), and the null allele of GSTM1 in multivariate analysis. The strongest evidence of modification was observed for rs1799931 (NAT2) on the relationship between pesticide poisoning and impaired vibration sense.ConclusionsDNA variants of NAT2, PON1, and GSTM1 may modify OP neurotoxicity, and this requires further exploration.

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