A novel method is reported for the stereoselective synthesis of highly functionalized allyl aryl sulfones. This protocol is based on a Pdcatalyzed three-component tandem reaction of sulfonyl hydrazides and aryl iodides with allenes and exhibits high (Z)-selectivity, good yields, minimal waste, ample product scope, and operational simplicity.
An efficient, molecular iodine-promoted MCR of alkynes and sulfonyl hydrazide for the synthesis of (E)-β-iodo vinylsulfone derivatives has been developed.
Two series of 2-aminopyrimidine derivatives possessing triazolopiperazine or 1,4,8-triazaspiro[4.5]decan-3-one scaffolds were designed, synthesized and evaluated for their biological activity.
A silver(I)‐ and base‐mediated formal [4+3] cycloaddition reaction of in situ generated 1,2‐diaza‐1,3‐dienes with in situ formed C,N‐cyclic azomethine imines has been developed. This protocol provided an efficient method for the synthesis of biologically important 1,2,4,5‐tetrazepine derivatives with a wild substrate scope and excellent functional group tolerance in moderate to excellent yields.magnified image
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