The corona virus disease 2019 (COVID-19) pandemic has become a global health emergency. The spike protein (S-protein) of SARS-CoV-2, consisting of S1 and S2 subunits, is critical to receptor recognition and virus-cell fusion. SARS-CoV-2 binds to host cell receptors via the receptor-binding domain (RBD) of S1, which induces the formation of 6-helical bundle (6-HB) between the two heptad repeats (HRs) in S2, namely HR1 and HR2, and the consequential conformational change of S2, which facilitates the virus-membrane fusion. In December 2020, several effective SARS-CoV-2 vaccines were authorized. However, the emergence of new SARS-CoV-2 strains attenuates the effi cacy of vaccines and neutralization antibodies. (1,2) Reduning Injection (热毒宁注射液, RDN), a p p r o v e d b y t h e C h i n e s e F o o d a n d D r u g Administration in 2005, is a Chinese medicine (CM) prepared from Lonicerae Japonicae Flos, Artemisiae Annuae Herba, and Gardeniae Fructus. CM has
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