Although several anticancer drugs have been introduced as chemotherapeutic agents, the effective treatment of cancer remains a challenge. Major limitations in the application of anticancer drugs include their nonspecificity, wide biodistribution, short half-life, low concentration in tumor tissue and systemic toxicity. Drug delivery to the tumor site has become feasible in recent years, and recent advances in the development of new drug delivery systems for controlled drug release in tumor tissues with reduced side effects show great promise. In this field, the use of biodegradable polymers as drug carriers has attracted the most attention. However, drug release is still difficult to control even when a polymeric drug carrier is used. The design of pharmaceutical polymers that respond to external stimuli (known as stimuli-responsive polymers) such as temperature, pH, electric or magnetic field, enzymes, ultrasound waves, etc. appears to be a successful approach. In these systems, drug release is triggered by different stimuli. The purpose of this review is to summarize different types of polymeric drug carriers and stimuli, in addition to the combination use of stimuli in order to achieve a better controlled drug release, and it discusses their potential strengths and applications. A survey of the recent literature on various stimuli-responsive drug delivery systems is also provided and perspectives on possible future developments in controlled drug release at tumor site have been discussed.

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Barley is long-identified as a functional food due to its content of micronutrients, β-glucans and vitamins. However, there is scant literature on a number of other nutritionally important biomolecules in the barley grain. This study determined the contents of four biomolecules, each with multiple known human and/or other animal health benefits, in the grains of 27 commercial barley cultivars and 7 landraces of barley from diverse countries of origin. These included the antioxidants, comprised of various vitamin E isomers and polyphenols, the osmoprotectant glycine betaine (GB) that protects cellular cytoplasm from osmotic shock, and the ‘plant stress hormone’ abscisic acid (ABA) which is endogenously expressed in humans and has multiple roles in physiology. All grains exhibited the presence of all biomolecules, suggesting they could potentially make some contribution to the health benefits of barley. The total vitamin E content varied between 19.20 - 54.56 μg/g DW, with α-tocotrienol being the major component (33.9 - 60.7%). The phenolics made up 3.21 - 9.73 mg gallic acid equivalent (GAE)/g DW, exceeding the amounts in the two major cereals, rice and wheat. GB ranged between 0.41-1.40 mg/g DW. The total vitamin E contents and GB typically exceeded those in corn. ABA ranged as 8.50 - 235.46 ng/g dry weight (DW), with the highest inter-variety variability. The data confirm barley to be an excellent source of these nutraceuticals, generally better than other major cereals. Our results thus offer more detailed insights into the potential of barley as a functional food and suggests the need to investigate in depth the health effects of this grain as well as the contribution of genetic and environmental factors.

Environmental challenges such as soil salinity and drought are serious threats to global food security and biodiversity, making the selection or development of stress-tolerant genotypes of crops and native plants necessary. Certain biochemical compounds synthesized by plants are directly involved in ameliorating the effects of environmental stress in characteristic ways. Further, the biochemical composition of edible parts of crops is directly related to human health, deficiencies of certain nutrients being associated with major health conditions and healthcare costs, and public awareness of functional foods also increasing. Interestingly, the unique biochemical properties of some biomolecules involved in plant stress tolerance are also associated with significant roles in human metabolism and health. This work summarises the biochemical properties and functions of four selected biomolecules with such dual significance, i.e., abscisic acid (a key hormone with roles in plant development and abiotic stress response), glycine betaine (a quaternary ammonium compound which functions as an osmoprotectant), vitamin E components (antioxidants), and phenolic compounds (antioxidants), all four also having significant nutraceutical effects.