Drug delivery in excess concentrations and at not-specified sites
inside the human body adversely affects the body and gives rise to
other diseases. Several methods have been developed to deliver the
drugs in required amounts and at specific targets. Nanoparticle-mediated
drug delivery is one such approach and has gained success at primary
levels. The effect of nanoparticles on the human body needs important
apprehension, and it has been unraveled by assessing the protein–nanoparticle
interactions. Here, we have measured the impact of silver nanoparticles
(AgNPs) on the human serum albumin (HSA) structure and function with
the help of all-atom molecular dynamics simulations (MDS). HSA is
a transport protein, and any change in the structure may obstruct
its function. The post MD analyses showed that the NP interacts with
HSA and the conjugated system got stabilized with time evolution of
trajectories. The present investigation confirms that the AgNP interacts
with HSA without affecting its tertiary and secondary structures and
in turn the protein function as well. AgNP application is recommended
in transporting conjugated drug molecules as it has no adverse effect
on serum proteins. Since HSA is present in the circulatory system,
it may open various applications of AgNPs in the biomedical field.
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