This study concerned with the synthesis and characterization of thiazolidinones & γlactams , the thiazolidinones compounds are prepared from A mixture of Schiff base (Imine) and thioglycolic acid, γlactams compounds are prepared from A mixture of Schiff base (Imine) with phenylsuccinic anhydride in moderate yields (52-71 %). The structures of these thiazolidinones and γ-lactams were established on the basis of the spectral data namely IR, 1 H-NMR, 13 C-NMR, 13 C-NMR DEPT , Mass spectra .
Ochratoxigenic fungal species are a major cause of various infections in plants and posed a serious threat to their consumers,including humans and animals. In the current study the objective was to examine the in vitro efficacy of different concentrations of leaves methanolic extract of S. helepense L. (Pers.) against target pathogenic ochratoxin producing fungal species (Trichoderma viride Pers., Trichoderma harzianum Rifai. and Cladosporium cladosporioides (Fresen.) G.A. de Vries).For this purpose, different concentrations viz. 2%, 4%, 6%, 8% and 10% of leaf methanolic extract were prepared and tested for antifungal potential in a completely randomized design (CRD). Results revealed that all the applied concentrations of S. helepense inhibited the growth of all the tested fungal strain. Maximum growth inhibition was observed in 2% of concentration of methanolic extract of S. helepense in case of C. cladosporoides i.e. 84%. On the other hand minimum reduction was observed in 4% of concentration of methanolic extract of S. helepense against T. viride as compared to control. The phytochemical analysis was also conducted to evaluate that which chemical entities were present that account for antifungal potency of methanolic extract of S. helepense. Results of phytochemical analysis revealed the occurrence of saponins, alkaloids, coumarins, flavonoids and tannins while the plant is devoid of terpenoids, phlobatanins and glycosides respectively. Hence it can be concluded that the methanolic leaf extract of the tested plant proved to be beneficial for inhibiting the growth of test ochratoxigenic fungi.
New thiazolidinones and γ-lactams were prepared from mixtures of Schiff base (imine) and thioglycolic acid or phenylsuccinic anhydride, respectively, in moderate yields (52-71 %). The structures of these new thiazolidinones and γ-lactams were established on the basis of the IR, 1 H-NMR, 13 C-NMR, 13 C-NMR DEPT and mass spectral data.
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