The relationship between Adverse childhood experiences (ACEs), resilience, and health outcomes has not been as thoroughly studied in adolescents. Adolescents completed the ACEs Questionnaire and a validated resilience measure (Child Youth Resilience Measure, or CYRM). Poor health outcome was having 1 or more: obesity, hypertension, and/or depression. 34.5% of teens had a poor health outcome, 38.6% had ACE scores of 4 or more, and resilience ranged from 45 to 84 (mean = 74.6). By univariate and bivariate analysis, ACEs (OR = 1.11, 95% CI = 1.03-1.19, P = .0039; OR = 1.08, 95% CI = 1.0-1.16, P = .045) and resilience (OR = 0.95, 95% CI = 0.92-0.98, P = .0016; OR = 0.96, 95% CI = 0.93-0.99, P = .016) were significantly associated with poor health outcome. Resilience relationship subscale was significantly associated with reduced health risk (OR = 0.85, 95%CI = 0.75-0.95, P = .005). ACEs are associated with poor health outcomes in adolescents, resilience is inversely related, and the caregiver relationship may be the driving force.
Background: Ebastine (EB) is a selective, nonsedating H1 antihistamine belonging to Class II(BCS); its insufficient water solubility limits its oral bioavailability. Cocrystal is one of the most modern techniques used to increase the solubility and dissolving rate of a medicine, among other physicochemical properties. Aim: The primary purpose of this study was to construct and assess EB cocrystal as an experiment to improve its solubility. Methods: Various processes, such as solvent evaporation and liquid asset grinding with varying molar ratios of amino acid as a co-former, have been used to produce cocrystals. The produced formulations were evaluated by yield %, drug content, saturation solubility, in vitro dissolution tests, Powder X-ray Diffraction (PXRD), and scanning electron microscopy. Results: Increased solubility by 364 times in distilled water with an improved dissolving profile. Conclusion: Due to its ability to enhance physicochemical and mechanical qualities, co-crystallization is a promising method for solid formation. Using unique hydrogen bond synthon motifs, co-crystals have been successfully produced from several medications and co-former
Abstract— Silica gel is a substance commonly used in desiccant wheel, which in turn is used in many applications to reduce moisture from the supplied air to a specific space. In this research, the effect of different operational conditions on the performance of silica gel wheel were studied. The desiccant wheel, which has been used, has a diameter of 55 cm and thickness of 20 cm. It contains 34 kg of silica gel and rotate at a speed of 30 rph. The theoretical performance coefficients of the desiccant wheel which have been studied include ,moisture removal capacity(MRC),dehumidification performance(DCOP),latent coefficient of performance (COPlat), and desiccant wheel effectiveness(ϵ_d). The theoretical investigation of these coefficients was done by using Novel Aire Technology software program (Simulation program of desiccant wheel) (2012). While the operational conditions like process air (humid air)inlet temperature between(30 to 43.4)0C, process air inlet humidity ratio between (0.011 to 0.019)kg/kgdry air ,regeneration air inlet temperature between (56.5 to 70)0C,and process air mass flow rate between(0.0814 to 0.199)kg/s. The results shows that the effectiveness and the moisture removal capacity have the same behavior increase with the increasing in mass flow rate from(0.0814 to 0.199) kg/s, humidity ratio from(11 to19)g/kgdry air, and regeneration air temperature from(56 t0 70)oC. But they reduces with increasing of inlet process air temperature from(30 to43.4)oC..
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