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Background Bipolar disorder (BD) is the 10th most common cause of frailty in young individuals and has triggered morbidity and mortality worldwide. Patients with BD have a life expectancy 9 to 17 years lower than that of normal people. BD is a predominant mental disorder, but it can be misdiagnosed as depressive disorder, which leads to difficulties in treating affected patients. Approximately 60% of patients with BD are treated for depression. However, machine learning provides advanced skills and techniques for better diagnosis of BD. Objective This review aims to explore the machine learning algorithms used for the detection and diagnosis of bipolar disorder and its subtypes. Methods The study protocol adopted the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. We explored 3 databases, namely Google Scholar, ScienceDirect, and PubMed. To enhance the search, we performed backward screening of all the references of the included studies. Based on the predefined selection criteria, 2 levels of screening were performed: title and abstract review, and full review of the articles that met the inclusion criteria. Data extraction was performed independently by all investigators. To synthesize the extracted data, a narrative synthesis approach was followed. Results We retrieved 573 potential articles were from the 3 databases. After preprocessing and screening, only 33 articles that met our inclusion criteria were identified. The most commonly used data belonged to the clinical category (19, 58%). We identified different machine learning models used in the selected studies, including classification models (18, 55%), regression models (5, 16%), model-based clustering methods (2, 6%), natural language processing (1, 3%), clustering algorithms (1, 3%), and deep learning–based models (3, 9%). Magnetic resonance imaging data were most commonly used for classifying bipolar patients compared to other groups (11, 34%), whereas microarray expression data sets and genomic data were the least commonly used. The maximum ratio of accuracy was 98%, whereas the minimum accuracy range was 64%. Conclusions This scoping review provides an overview of recent studies based on machine learning models used to diagnose patients with BD regardless of their demographics or if they were compared to patients with psychiatric diagnoses. Further research can be conducted to provide clinical decision support in the health industry.

Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is lagging in many parts of the world, including the Middle East, mainly due to the lack of data on the distribution of actionable pharmacogenomic variation in these ethnicities. We analyzed 6,045 whole genomes from the Qatari population for the distribution of allele frequencies of 2,629 variants in 1,026 genes known to affect 559 drugs or classes of drugs. We also performed a focused analysis of genotypes or diplotypes of 15 genes affecting 46 drugs, which have guidelines for clinical implementation and predicted their phenotypic impact. The allele frequencies of 1,320 variants in 703 genes affecting 299 drugs or class of drugs were significantly different between the Qatari population and other world populations. On average, Qataris carry 3.6 actionable genotypes/diplotypes, affecting 13 drugs with guidelines for clinical implementation, and 99.5% of the individuals had at least one clinically actionable genotype/diplotype. Increased risk of simvastatin-induced myopathy could be predicted in ~32% of Qataris from the diplotypes of SLCO1B1, which is higher compared to many other populations, while fewer Qataris may need tacrolimus dosage adjustments for achieving immunosuppression based on the CYP3A5 diplotypes compared to other world populations. Distinct distribution of actionable pharmacogenomic variation was also observed among the Qatari subpopulations. Our comprehensive study of the distribution of actionable genetic variation affecting drugs in a Middle Eastern population has potential implications for preemptive pharmacogenomic implementation in the region and beyond.

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Ophiophagus Hannah is extensively dispersed throughout various portions of the Asia. Many toxin proteins have been identified from their venom which are pharmacology active. Current research goals is to investigate the structural and function assessment of a hypothetical protein L345_13461 of Ophiophagus hannah for a better understanding of king cobra venom. Using in silico approach, the 3D structure was generated by Homology modelling, while the functions was profiled by ProFunc tool. The primary and secondary structure analysis revealed that the hypothetical protein L345_13461 is a stable and located in cytoplasm comprising of a remarkable number of random coils. Homology modelling was accomplished employing SWISS-MODEL server where the templates identity of 34.76% was observed with PDB ID 5ZZ3. Quite a few evaluations of quality assessment and validation parameters created a stable protein model with prodigious quality. Functional analysis was accomplished through InterProScan, ProFunc, DeepGoPlus and KEGG KAAG, suggesting that the hypothetical protein is a cytoplasmic protein, which plays important roles in protein binding, metabolism, signalling and cellular processes, genetic information processing. Finally, we proposed that experimental support would assist to investigate the structures and functions of other hypothetical proteins of various living organisms.

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SARS-CoV-2, a new world coronavirus belonging to class Nidovirales of Coronaviridae family causes COVID-19 infection which is the leading cause of death worldwide. Currently there are no approved drugs and vaccines available for the prevention of COVID-19 infection, although couples of immunizations are being tested in clinical trials. However, the present efforts are focused on computational vaccination technique for evaluating candidates to design multi-epitope-based vaccine against pathogenic mechanism of novel SARS-COV-2. Based on recent published evidence, we recognized spike glycoprotein and envelope small membrane protein are the potential targets to combat the pathogenic mechanism of SARS-CoV-2. Similarly, in the present study we identified epitope of both B and T cell associated with these proteins. Extremely antigenic, conserve, immunogenic and nontoxic epitope of B and T cell of Spike protein are WPWYVWLGFI, SRVKNLNSSEGVPDLLV whereas the CWCARPTCIK and YCCNIVNVSL are associated with envelope small membrane protein were selected as potential candidate for vaccine designing. These epitopes show virtuous interaction with HLAA0201 during molecular docking analysis. Under simulation protocol the predicted vaccine candidates show stability. Collectively, this work provides novel potential candidates for epitope-based vaccine designing against COVID-19 infection.

BACKGROUND Bipolar disorder (BD) is the tenth common cause of frailty in young individuals and has triggered morbidity and mortality worldwide. BD patients have 9–17 years lower lifetime as compared to the normal population. It is a predominant mental disorder but misdiagnosed as depressive disorder that leads to difficulties in the treatment of affected patients. 60% of patients with bipolar disorder are looking for the treatment of depression. However, machine learning provides advanced skills and techniques for the better diagnosis of bipolar disorder. OBJECTIVE This review aims to explore the machine learning algorithms for the detection and diagnosis of bipolar disorder and its subtypes. METHODS The study protocol adapts PRISMA extension guidelines. It explores three databases, which were Google scholar, ScienceDirect, and PubMed. To enhance the search, we performed backward screening of all the references of the included studies. Based on the predefined selection criteria, two levels of screening were carried out: the title and abstract review and the full review of the articles that met the inclusion criteria. Data extraction was performed independently by all investigators. To synthesize the extracted data, a narrative synthesis approach was followed. RESULTS 573 potential articles were retrieved from three databases. After pre-processing and screening, only 33 articles were identified, which met our inclusion criteria. The most commonly used data belonged to the clinical category (n=22, 66.66%). We identified 8 machine learning models used in the selected studies, Support-vector machines (n=9, 27%), Artificial neural network (n=4, 12.12%) , Linear regression (n=3, 0.9%) , Gaussian process model (n=2, 0.6%), Ensemble model (n=2, 0.6%) , Natural language processing (n=1, 0.3%), Probabilistic Methods (n=1, 0.3%), and Logistic regression (n=1, 0.35%). The most common data utilized was magnetic resonance imaging (MRI) for classifying bipolar patients compared to other groups (n=11, 34%) while the least common utilized data was microarray expression dataset and genomic data. The maximum ratio of accuracy was 98% while the minimum accuracy range was 64%. CONCLUSIONS This scoping review provides an overview of recent studies based on machine learning models used to diagnose bipolar disorder patients regardless of their demographics or if they were assessed compared to patients with psychiatric diagnoses. Further research can be conducted for clinical decision support in the health industry. CLINICALTRIAL Null