Basidiobolomycosis is a rare fungal infection with high prevalence in southwestern province of Saudi Arabia (Tohama region); it mainly causes subcutaneous infections and rarely gastrointestinal disease. Because of its indolent presentation, it is often misdiagnosed as IBD, tuberculosis or Malignancy.We are reporting a 7 year old Saudi girl with abdominal mass, fever and eosinophilia resembling malignancy on radiological and pathological picture fully recovered with only medical therapy in the form of oral Voriconazole 2012 Elsevier Ltd. All rights reserved.

Fortunately, coronavirus disease 2019 (COVID-19) infection in pediatric populations exhibits a mild course of disease. However, a small number have recently been identified who develop a significant systemic inflammatory response, a new disease entity called multisystem inflammatory syndrome in children (MIS-C), especially after the peak of the wave in Al-Ahsa, Saudi Arabia, in early June to mid-July. In MIS-C children usually present a few days to a few weeks after recovery from COVID-19 with high grade fever, GI symptoms, Kawasaki-like picture or even toxic shock-like syndrome. Raising awareness about this disease entity is very fundamental to enable pediatricians and other health care providers to identify and manage these patients before it is too late. We describe 10 different cases of MIS-C with different risk factors and presentations.

Background: During the long wait and the global anxiety for a vaccine against COVID-19, impressively high-safety and effective vaccines were invented by multiple pharmaceutical companies. Aim: We aimed to assess the attitudes of healthcare providers and evaluate their intention to advocate for the vaccine. Methods: This was a cross-sectional study conducted in a tertiary private hospital where an electronic survey was distributed among healthcare providers (HCPs). The survey contained two sections: socio-demographic characteristics and Likert-scale perception, with 72% internal consistency. Results: The response rate to the email survey was 37% (n = 236). In addition, 169 (71.6%) of respondents were women, with more than half (134, 56.8%) aged ≤35 years. A total of 110 (46.6%) had over 10 years of experience, and most of them were nurses (146, 62%). Univariate analysis revealed that older participants significantly accepted and advocated for the new vaccine more than the younger ones. In the multivariate analysis, men were significantly more likely than women to accept and advocate for the new vaccine, as were those with chronic illnesses. Participants with allergy were significantly less likely to accept the vaccine than others. odds ratio (OR) and p-values were 2.5, 0.003; 2.3, 0.04; and 0.4, 0.01, respectively. Conclusion: The acceptance rate for the newly-developed COVID-19 vaccines was average among HCPs. Sex, age, presence of chronic illnesses, and allergy were significant predictors of accepting the vaccine.

Objective To assess the efficacy of Favipiravir compared to the standard therapy in treating patients with severe COVID-19 infection. Methods This is a retrospective cohort of patients with COVID-19 pneumonia who were treated with favipiravir, versus comparison group that received the standard of care. Results A total of 226 patients were included; 110 patients received favipiravir and 116 patients received standard of care. Patients who received favipiravir had longer time to recovery (14.2 ± 8.8 versus 12.8 ± 5.2, p = 0.17 ). Favipiravir was associated with an improved early day 14 mortality (4 [3.6%] versus 11 [9.5%]), p = 0.008), but was associated with a higher day 28 mortality (26 [23.6%] versus 11 [9.5%], p = 0.02). The overall mortality was higher in the favipiravir versus the standard of care group but difference was not statistically significant (33 [30.0%] versus 24 [20.7%], p = 0.10). Conclusion The addition of favipiravir to standard of care was not associated with any improvement in clinical outcomes or mortality. Larger randomized controlled clinical trials are needed to further assess the efficacy of favipiravir.

BackgroundInvasive candidiasis in children is associated with high morbidity and mortality. We aim to identify predisposing factors, species distribution, antifungal susceptibility, and outcomes among patients with candidemia.MethodsA data collection form composed of seven sections including 51 questions was designed to gather demographic and clinical information. We collected data from all 129 patients with invasive candidiasis from January 2010 to January 2015.ResultsThe 129 patients had the following risk factors: 30 (23.26%) were premature, 34 (26.36%) had low birth weight, 59 (45.74%) had a central venous catheter, 21 (16.28%) had a malignancy, 20 (15.5%) received immunotherapy, and 56 (43.41%) received ventilator support. A multivariate analysis revealed a more than two-fold mortality rate in patients who had vegetation in the heart (OR 2.9), and patients who had Candida isolated from their blood were more than twice as likely to die as patients with Candida isolated from other sites (OR 2.2). A total of 48.33% of patients on ventilator support died, and 26.09% of patients who were not on ventilator support died (P = 0.009); 43.75% of patients in the intensive care unit (ICU) died vs. only 24.49% of patients who were not in the ICU (P = 0.03). C. parapsilosis exhibited the highest mortality rate among all Candida species (56.2%).ConclusionThe study revealed that C. albicans was the most common isolate among all Candida species. Mechanical ventilation and an ICU stay were significant risk factors for death in children with invasive candidiasis.Disclosures All authors: No reported disclosures.

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Pott's puffy tumor (PPT) is a very rare, nearly forgotten condition. We describe a 9-year-old girl with PPT due to trauma and surgical cultures that revealed Aspergillus fumigatus.

Adenovirus is a common virus that usually affects children. It is mostly associated with respiratory or gastrointestinal diseases and rarely causes neurological manifestations. In this case we describe a 2-year-old girl with adenovirus pneumonia complicated with transient encephalopathy.