Functional forces might also lead to fracture after endodontic treatment. This might occur secondary to exposure to erosion, abrasion, physical trauma, and caries. Interventing against these events can be achieved by conducting long follow-up periods and enhancing the endodontic treatment approaches. The current endodontic treatment modalities aim at tissue preservation to enhance resistance to fractures and prevent potential post-treatment complications. In this context, evidence shows the validity of minimally invasive modalities in endodontic treatment with favorable outcomes and reduced frequency of complications. In the present literature review, we have discussed the efficacy of minimally invasive biological treatment in endodontics. It is vital to maintain the integrity of the structures of the tooth-related paracervical area, particularly when treating molars. This is attributed to enhancing the long-term survival rates of the pericervical dentin of these teeth. The current trends represent a revolution in the field of endodontic treatment. This is attributed to the novel development of the various disinfection modalities, which do not need to shape the canal into a round form and induce flaring reactions. Overall, the main advantages of vital pulp therapy include being simple, reduced cost, and reduced risk of treatment-related complications secondary to overcoming the difficulties with the anatomy of the root canals.