Background-Gastric adenocarcinoma is a leading cause of cancer mortality. The role of DARPP-32 overexpression in the gastric tumorigenesis cascade remains unclear.
Background Midodrine is prescribed to prevent symptomatic hypotension and decrease complications associated with hypotension during dialysis. We hypothesized that midodrine use before kidney transplantation may be a novel marker for posttransplant risk. Methods We analyzed integrated national U.S. transplant registry, pharmacy records and Medicare claims data for 16,308 kidney transplant recipients transplanted 2006–2008, of whom 308 (1.9%) had filled midodrine prescriptions in the year prior to transplantation. Delayed graft function (DGF), graft failure and patient death were ascertained from the registry. Posttransplant cardiovascular complications were identified using diagnosis codes on Medicare billing claims. Adjusted associations (adjusted hazards ratio) of pretransplant midodrine use with complications at 3 and 12 months posttransplant were quantified by multivariate Cox regression, including propensity for midodrine exposure. Results At 3 months, patients who used midodrine pretransplant had higher rates of DGF, 32% vs. 19%; hypotension, 14% vs. 4%; acute myocardial infarction, 4% vs. 2%; cardiac arrest, 2% vs. 0.9%, graft failure, 5% vs. 2%; and death, 4% vs. 1% than non-users (P<0.05). After multivariate adjustment including recipient, and donor factors, as well as for the propensity of midodrine exposure, pretransplant midodrine use was independently associated with risks of DGF (adjusted odd ratio 1.95; CI 1.49–2.56), death-censored graft failure (adjusted hazard ratio (aHR) 1.94; CI 1.14–3.27), and death (aHR 3.55; CI 1.99–6.33). Patterns were similar at 12 months. Conclusions Although associations may in part reflect underlying conditions, the need for midodrine before kidney transplantation is a risk marker for complications including DGF, graft failure, and death.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.