AimThe amount of energy deposited on any organ by ionising radiation termedabsorbed dose, plays an important role in evaluating the risks associated with the administration of radiopharmaceuticals. In this research work, the absorbed dose received by human organs for153Sm-TTHMP and153Sm-PDTMP was evaluated based on biodistribution studies on the Syrian rats.Materials and methods153Sm-TTHMP and153Sm-PDTMP were successfully prepared with radiochemical purity of higher than 99%. The biodistribution of the complexes was investigated within the Syrian rats up to 48 hours post injection. The human absorbed dose of the complexes was estimated by the radiation dose assessment resource method.ResultsThe highest absorbed dose for153Sm-TTHMP and153Sm-PDTMP was observed in the trabecular bone with 1·085 and 1·826 mGy/MBq, respectively. The bone to other critical organ dose ratio for153Sm-PDTMP is significantly greater than153Sm-TTHMP. Also, the bone/red marrow dose ratio for these complexes is comparable with this ratio for153Sm-EDTMP, as the most clinically used Sm-153 bone pain palliative radiopharmaceutical.FindingsAccording to the considerable bone absorbed dose against the insignificant absorbed dose of non-target organs, these complexes can be used as potential bone pain palliative agents in clinical applications.
Since content audiences, including libraries and information centres, are increasingly geared to digital environments and virtual networks, the production and delivery of high-quality digital content are becoming continuously important. So far, several components have been introduced by researchers for evaluating the quality of digital content generation. However, due to the uncertainty of the importance rate and value of each of these components, it has not yet been possible to use them effectively to evaluate the content produced. This study aimed to rank the components of content generation to allow accurate evaluation of them for users as well as content providers and distributors including libraries and marketers. The ranked content can motivate digital content producers and distributors to better evaluate the quality of digital content, better attract customers and make more effective decisions about the quality of digital content use based on their specific goals. Initially, 42 of the most important components were identified from the literature. Then, the next steps were taken to rank these components, and based on three rounds of Delphi interviews, the experts’ views on the importance rate of each of the components were obtained, analysed and ranked. Since in this ranking, the importance of a wide range of components should be highlighted towards each other, the fuzzy TOPSIS technique was emphasised for analysing the views of 16 experts in the field of content generation in Iran. This ranking indicated that components such as ‘findable and access’, ‘non-disturbing and helpful’, ‘clear’ and ‘remarkable’ are the main pillars of content generation and are of the utmost importance. The results can be used as an effective tool to improve the quality of content. Moreover, it increases audience engagement in digital environments and social networks, and encourages them to make more use of the digital content of libraries.
Therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs or tissues with an aim of minimizing unwanted radiation to surrounding healthy tissue. In this work, [tris(1,10-phenanthroline)[ 153 Sm]samarium(III)]trithiocyanate ( 153 Sm-TPTTC) was developed for possible therapeutic properties. The cold compound, i.e. nat Sm-TPTTC was prepared and characterized by IR, UV, mass and 1 H-NMR spectroscopy. 153 Sm-TPTTC was prepared in two steps using [ 153 Sm]SmCl 3 , obtained by neutron activation of an enriched 152 Sm sample. Stability tests, partition coefficient determination, toxicity tests and biodistribution studies of the complex in wild-type and fibrosarcoma-bearing mice were determined. The radiolabeled complex was prepared in high radiochemical purity (> 99% precipitation method) and specific activity of 278 GBq/mmol and demonstrated significant stability at 4, 25 and 37 • C (in presence of human serum). Initial complex biodistribution data showed significant liver accumulation in wild-type mice and significant tumor accumulation in fibrosarcoma-bearing mice with tumor : blood and tumor : muscle ratios of 3.55 (2 h) and 38.26 (96 h) respectively. 153 Sm-TPTTC properties suggest an efficient tumor targeting agent with high tumor-avidity. Further investigation on the therapeutic properties must be conducted.
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