Chronic lymphocytic leukemia (CLL) is a malignant, low-grade, monoclonal disorder characterized by the accumulation of lymphocytes with variable clinical features. Cutaneous manifestations or leukemia cutis are non-specific, uncommon presentations of CLL and can present in many different ways. In this case report, we discuss a 76-year-old male who presented with skin lesions of the lower limbs and severe itching. Due to the lack of response to the treatment with topical corticosteroids, initial tests were carried out. Complete blood count results indicated lymphocytosis. Eventually Ultimately, the skin lesions led to the diagnosis of CLL. The patient was treated with bendamustine-rituximab (BR). After receiving the treatment, all cutaneous manifestations and generalized itching disappeared. This case highlights the importance of comparing similar cases of CLL presented with dermatological conditions in order to to understand proper management and practice.
Background: The concurrent presentation of non-Hodgkin lymphoma and multiple myeloma is a very rare condition and only few cases have been reported. Case Presentation: In this case report, we discuss a patient who presented with abdominal pain, weight loss, and melena. After the patients admission, several examinations were conducted. Microscopic findings in pathological studies and immunohistochemistry staining studies revealed a malignant non-Hodgkin B-cell lymphoma. A monoclonal free light chain protein was documented in the urine protein electrophoresis. Serum protein electrophoresis was reported to be normal. Bone marrow biopsy demonstrated cellularity plasma cell aggregations as multiple myeloma. Small bowel segmental resection surgery was the treatment plan. To prevent the relapse of chemotherapy, rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy was tolerated by the patient. Finally, melena did not last after the resection and hemoglobin returned to its normal range. Conclusion: In conclusion, this case report suggests that both multiple myeloma and non-Hodgkins lymphoma are hematopoietic malignancies which originate from B-cell lymphocytes. To understand, properly manage, and treat this rare condition, multiple studies are required, and this can be achieved by comparing similar cases.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.