Highly stereoselective synthesis of saccharin derivatives containing functionalized 2-azetidinone moiety was achieved starting from saccharin as an available precursor. The approach to these valuable heterocyclic scaffolds involves a formal [2π + 2π] cycloaddition between Schiff bases and the saccharinylketene as a novel ketene which was generated in situ and an electrocyclic reaction of a zwitterionic intermediate. The identification of the ketene was confirmed by reaction with the stable free radical TEMPO (TO•). Also, the antimicrobial activities of some new substituted saccharin against nine standard bacteria, four bacteria which were isolated from clinical samples and one yeast, were evaluated.
Highly Stereoselective Synthesis of Saccharin-Substituted -Lactams via in situ Generation of a Heterosubstituted Ketene and a Zwitterionic Intermediate as Potential Antibacterial Agents. -The approach to the saccharin-substituted -lactams involves a formal [2 + 2] cycloaddition between an in situ generated saccharinylketene and the Schiff bases followed by an electrocyclic reaction of the resulting zwitterionic intermediate. Selected products are evaluated for their antimicrobial activities, but only compounds (IIIc) and (Vb) show an antibacterial effect. -(MORTAZAVI, Z. F. A.; ISLAMI*, M. R.; KHALEGHI, M.; Org. Lett. 17 (2015) 12, 3034-3037, http://dx.doi.org/10.1021/acs.orglett.5b01309 ; Dep. Chem., Shahid Bahonar Univ., Kerman 67149, Iran; Eng.) -H. Haber 43-112
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