Highlights d Sgms2 À/À and Aicda-Cre/Prkcd f/f mice exhibit similar B cell and lupus-like phenotypes d SMS2 is highly upregulated and promotes PKCd-mediated apoptosis in anti-DNA GC B cells d B cells from patients with lupus have abnormally low SMS2 expression d Pharmacologic activation of SMS2 attenuates lupus pathogenesis in NZBWF1 mice
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